Publications by authors named "Tatiana D'Annibale Orsi"
Article Synopsis
- - Clostridioides difficile (CD) is the leading cause of diarrhea in healthcare settings, and its severity has grown due to more aggressive strains.
- - The primary factor for CD's virulence is toxin production, but the study found other important genetic factors contributing to its virulence.
- - Researchers sequenced 38 strains and found most were toxigenic, with some lacking genes related to adhesion, highlighting the need to explore other virulence factors for a better understanding of CD.
Little is known about the role of lineage of strains of Clostridioides difficile (CD) on the clinical presentation of CD infection (CDI) in Latin America, especially regarding the treatment response. We conducted a multicenter, prospective study to investigate the predictive factors and treatment outcomes of CDI in hospitalized patients and to performed phenotypical and molecular characterization of CD strains. A total of 361 diarrheic patients at 5 hospitals from different regions of the country were enrolled.
View Article and Find Full Text PDFEpidemiological data on CD infection (CDI) in Latin American are scarce. CDI prevalence and strains characterization were prospectively evaluated in 5 Brazilian hospitals from different regions. Prevalence rates of CDI were 15%, ranging from 0 to 37%.
View Article and Find Full Text PDFArticle Synopsis
- Multidrug-resistant Gram-negative bacteria, including Enterobacterales, pose a global health threat as treatment options decrease, leading to this study focusing on 50 resistant isolates and their susceptibility to less-used antibiotics.
- The study examined various strains, revealing that many carried resistance genes, with a high prevalence of antimicrobial resistance and variable susceptibility to older drugs like tigecycline, minocycline, and ceftazidime/avibactam.
- Results indicated that while tigecycline exhibited promising effectiveness against most Gram-negative strains, other antibiotics like chloramphenicol showed poor performance, highlighting the need for continued research on alternative treatments.
Article Synopsis
- Pseudomonas aeruginosa is a dangerous bacterium, particularly for hospitalized and immunocompromised patients, and polymyxins are the last line of defense against it.
- A new polymyxin-resistant strain of P. aeruginosa (ST245) has been reported for the first time in Brazil, linked to a patient with ventilator-associated pneumonia.
- Genome analysis revealed multiple resistance and virulence genes, indicating a potential public health risk and the spread of unusual antibiotic resistance patterns in the country.