Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial.

Objective: To compare the safety and efficacy of quinine given by the rectal route with quinine given by the intramuscular route in children with moderately severe Plasmodium falciparum malaria.

Design: Randomised, open, clinical trial.

Setting: Health centre in Burkina Faso.

Dose-dependent resorption of quinine after intrarectal administration to children with moderate Plasmodium falciparum malaria.

The pharmacokinetics of increasing doses of an intrarectal Cinchona alkaloid combination containing 96.1% quinine, 2.5% quinidine, 0.