Cladoic Acid, an Anti- Polyketide from sp. TP-F2020.

A new polyketide, cladoic acid, was isolated from a fungus of the genus . The structure of the highly oxygenated -decalin ring with an all- triene side chain was elucidated by extensive spectroscopic analysis. The unique chair/twist-boat conformation of the -decalin core and the flexibility of the B-ring were demonstrated by computer-aided conformational analysis.