Publications by authors named "Tatiana Arcos"
Article Synopsis
- Voltage-gated sodium channels (VGSCs) and cell adhesion molecules are usually viewed as separate, but they actually cluster together at specific spots in cardiac muscle, much like in myelinated fibers.
- Advanced imaging and simulations reveal that N-cadherin and the VGSC NaV1.5 form distinct hubs at cardiac intercalated discs.
- The association of N-cadherin with NaV1.5 boosts cardiac sodium current and enhances intercellular adhesion, suggesting these hubs are crucial for both electrical and mechanical heart function and might be involved in heart diseases linked to VGSC mutations.
