Publications by authors named "Tatiana Araujo Pereira"
The redox reactivity of iron is a double-edged sword for cell functions, being either essential or harmful depending on metal concentration and location. Deregulation of iron homeostasis is associated with several clinical conditions, including viral infections. Clinical studies as well as in silico, in vitro and in vivo models show direct effects of several viruses on iron levels.
View Article and Find Full Text PDFManganese (Mn) is an essential trace element and trivalent Mn complexes have been used as oxidation catalysts and enzyme mimetics. We studied the cytotoxicity of Mn(III) derivatives of citrate, pyrophosphate and salicylene diamine (respectively, MnCit, MnPPi and EUK8) toward HeLa cells stressed by ultraviolet irradiation and the effect of the co-administration of ascorbate and para-amino salicylate (PAS) on cell viability. Metal complexes enhanced the lethality of irradiated cells, and this effect was even more pronounced when ascorbate was co-administered with Mn(III) species.
View Article and Find Full Text PDFArticle Synopsis
- The development of alloantibodies against factor VIII is a major complication in treating congenital hemophilia A, affecting patient outcomes.
- During a study from 1993 to 2006, data was collected on patients' inhibitor tests and factor infusions, showing that 12% tested positive for inhibitors at least twice.
- Most patients with low inhibitor levels (< 5 BU/ml) achieved a sustained negative status, suggesting that immune tolerance induction may not be necessary for those with lower inhibitor titres.
- Further research is needed to identify factors influencing sustained negative status in regions lacking ITI treatment options.