Structural, enzymatic and pharmacological profiles of AplTX-II - A basic sPLA (D49) isolated from the Agkistrodon piscivorus leucostoma snake venom.

A basic sPLA (D49) from the venom of snake Agkistrodon piscivorus leucostoma (AplTX-II) was isolated, purified and characterized. We determined the enzymatic and pharmacological profiles of this toxin. AplTX-II was isolated with a high level of purity through reverse phase chromatography and molecular exclusion.