Publications by authors named "Tathiany I Silva"
Article Synopsis
- The role of nitric oxide (NO) in cerebral malaria is debated, and its associated cognitive impairments highlight the need for new therapies to prevent long-term effects after recovery from Plasmodium falciparum infection.
- Elevated nitric oxide levels from the enzyme inducible nitric oxide synthase (iNOS) may lead to neurological damage and cognitive decline through harmful nitrogen-reactive intermediates, necessitating research into its impact.
- Studies in mice treated with aminoguanidine (an iNOS inhibitor) or lacking the iNOS enzyme showed reduced signs of cerebral malaria and improved cognitive function, emphasizing the potential benefits of targeting iNOS to mitigate both the disease and its long-term cognitive effects.
Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal. Leukocyte integrins are essential for host defense but also mediate physiologic responses of the innate and adaptive immune systems. We previously showed that targeted deletion of the αD subunit (αD-/-) of the αDβ2 integrin, which is expressed on key leukocyte subsets in mice and humans, leads to absent expression of the integrin heterodimer on murine macrophages and reduces mortality in mice infected with Plasmodium berghei ANKA (P.
View Article and Find Full Text PDFCerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection in children and non-immune adults. Previous work has documented a persistent cognitive impairment in children who survive an episode of CM that is mimicked in animal models of the disease. Potential therapeutic interventions for this complication have not been investigated, and are urgently needed.
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