Neurofibrillary degeneration in a case of quadriplegia and myoclonic movement.

A case of spastic quadriplegia with myoclonic movement was studied by both light and electron microscope. Argentophilic inclusions were found in a unique distribution involving the cerebral cortex, brain stem, cerebellum, and the spinal cord, including the motor neuron system. The fine structure of the inclusions consisted of accumulation of previously undescribed straight or wavy tubules approximately 120A wide devoid of periodic constriction.

[An autopsy case of bilateral cavities in the temporal white matter and the striatum (author's transl)].

A 24-year-old female developed high fever and unconsciousness for several days at the age of 3. She was said to have meningitis. Subsequently her verbal development was markedly retarded so that she was kept at a deaf-and-dumb institute.

Chronic alcoholism: report of an autopsy case and comparison with pseudoulegyric type of hepatocerebral degeneration.

An autopsy case diagnosed as chronic alcoholism was reported. He clinically showed progressive neurological illness. His CNS lesions were composed of disseminated necrotic foci in the cerebral cortices with many Alzheimer type II astrocytes, pachymeningitis hemorrhagica interna, and lesions similar to pellagra and Wernicke encephalopathy.

Neurotoxicity with chloramphenicol--an electron microscopic study.

The peripheral nerve and spinal ganglion of chloramphenicol-administered and normal animals were examined mainly with the electron microscopy. The experimental animals consisted of three dogs and one rabbit. They were highly injected or given orally high doses of chloramphenicol with a duration from 70 to 130 days.

Neurotoxity of iodoxyquinoline: a further study on beagle dogs.

Eight beagle dogs were treated orally with iodoxyquinoline (chinoform, clioquinol) again, and all of them manifested similar neurologic symptoms to those observed in our previous experiments on mongrel dogs, beagle dogs, cats and a monkey. The neurologic symptoms were identical both clinically and pathologically with those of subacute myelo-optico-neuropathy (abbreviated to SMON) in man. In the present study, the neurologic manifestations evolved with less total chinoform doses (5.