Publications by authors named "Tate K"

Background: Adult day programs aim to facilitate aging in place by supporting the health and well-being of persons with dementia and providing respite to their caregivers. However, studies on the effects of day programs are inconclusive, and we especially lack insights into the context conditions and mechanisms of day programs that may produce different outcomes for different groups of persons with dementia and their caregivers. Our objective was to conduct a realist review, synthesizing research on day programs to develop program theories explaining how and why day programs do or do not produce positive or negative outcomes for different groups of persons with dementia, and caregivers.

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Background: Adult day programs provide critical supports to older adults and their family or friend caregivers. High-quality care in the community for as long as possible and minimizing facility-based continuing care are key priorities of older adults, their caregivers, and health care systems. While most older adults in need of care live in the community, about 10% of newly admitted care home residents have relatively low care needs that could be met in the community with the right supports.

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Article Synopsis
  • DEBCT is a new cell therapy that creates skin grafts from patients’ own iPS cells to treat Dystrophic Epidermolysis Bullosa (DEB).
  • This method combines CRISPR gene editing with cell reprogramming for faster production of corrected cells, leading to effective and diverse skin cell types.
  • Early studies show that these grafts are safe and can effectively improve skin conditions in DEB patients within a month of treatment.
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Background/objectives: Transitions to and from Emergency Departments (EDs) can be detrimental to long-term care (LTC) residents and burden the healthcare system. While reducing avoidable transfers is imperative, various terms are used interchangeably including inappropriate, preventable, or unnecessary transitions. Our study objectives were to develop a conceptual definition of avoidable LTC-ED transitions and to verify the level of stakeholder agreement with this definition.

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Aims: To understand factors influencing nurse manager retention or intention to leave, develop a preliminary theoretical model and identify strategies and interventions for workforce planning.

Design: Systematic review update of literature with integrated design of mixed research synthesis.

Methods: We included peer-reviewed articles examining factors influencing retention or intention to leave for front-line, middle or patient care nurse managers.

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Introduction: Decisions about nurse staffing models are a concern for health systems globally due to workforce retention and well-being challenges. Nurse staffing models range from all Registered Nurse workforce to a mix of differentially educated nurses and aides (regulated and unregulated), such as Licensed Practical or Vocational Nurses and Health Care Aides. Systematic reviews have examined relationships between specific nurse staffing models and client, staff and health system outcomes (eg, mortality, adverse events, retention, healthcare costs), with inconclusive or contradictory results.

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Background And Objectives: Older adults residing in residential aged care facilities (RACFs) often experience substandard transitions to emergency departments (EDs) through rationed and delayed ED care. We aimed to identify research describing interventions to improve transitions from RACFs to EDs.

Research Design And Methods: In our scoping review, we included English language articles that (a) examined an intervention to improve transitions from RACF to EDs; and (b) focused on older adults (≥65 years).

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Aim: To examine trends in quality of work life and health outcomes of managers in nursing homes in Western Canada pre-pandemic.

Methods: A repeated cross-sectional descriptive study using data collected in 2014-2015, 2017 and 2019-2020, in the Translating Research in Elder Care Programme. Self-reported measures of demographics, physical/mental health and quality of work life (eg, job satisfaction, burnout, work engagement) were administered and completed by nursing home managers.

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Article Synopsis
  • FOXP3 is a key transcription factor for regulatory T cell (Treg) function, and defects in Tregs can lead to autoimmune diseases like IPEX due to genetic mutations.
  • A phase I clinical trial has been initiated for IPEX patients using engineered Treg-like cells to improve treatment outcomes and reduce the need for immunosuppressive drugs.
  • A new humanized-mouse model (hu-mouse) was developed using CRISPR to knock out FOXP3, mimicking IPEX symptoms, and showed that injection of CD4 cells could restore Treg functions and control disease symptoms, making it a valuable tool for pre-clinical studies.
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Background: Despite decades of advocates striving to enhance gerontological content in baccalaureate nursing programs, nurses are still graduating with inadequate knowledge and skills to work with older adults. Scholars suggest that incorporating entry-to-practice gerontological competencies could be one way to improve graduating nurses' knowledge about older adults.

Aim: To examine the state of gerontological entry to practice competencies and standards for baccalaureate-prepared nurses around the world.

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Objective: To identify sociodemographic, health condition, and organizational/process factors associated with pressure injury (PI) incidence during older adults' emergency transitions from long-term care (LTC) to the ED.

Methods: Emergency transitions were tracked for older adults within included LTC facilities to participating EDs in two urban centers located in provinces in Canada. Binary logistic regression was used to examine the influence of sociodemographic, service use, and client health and function factors on the incidence of PIs during transitions from LTC facilities to EDs.

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Background: Surgical culture is often referenced but not well defined. Recent research and changing policies in graduate medical education have influenced the training paradigm and expectations of surgical trainees. It is unclear how these changes impact surgeons' understanding of surgical culture today and how those views impact surgical training.

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Background: Stent is widely regarded as the main treatment for curing cardiovascular diseases such as stenosis. Previous research has revealed that the damage of endothelial cells (EC), i.e.

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Aim: To examine the influence of hospital culture and authentic leadership on the effects of quality improvement practices on patient satisfaction.

Background: Nurses in formal leadership roles shape and are shaped by organizational culture to achieve high performance standards to influence quality of care.

Design: Using structural equation modelling, we tested a model on quality improvement practices across three participant groups that differed based on authentic leadership and hospital culture.

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Per- and polyfluoroalkyl substances (PFAS) are present in landfill leachate, posing potential challenges to leachate disposal and treatment. This work represents the first study of a thin-water-film nonthermal plasma reactor for PFAS degradation in landfill leachate. Of the 30 PFAS measured in three raw leachates, 21 were above the detection limits.

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Background: Documentation during resident transitions from long-term care (LTC) to the emergency department (ED) can be inconsistent, leading to inappropriate care. Inconsistent documentation can lead to undertreatment, inefficiencies and adverse patient outcomes. Many individuals residing in LTC have some form of cognitive impairment and may not be able to advocate for themselves, making accurate and consistent documentation vital to ensuring they receive safe care.

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Glioblastoma is an aggressive brain cancer characterized by diffuse infiltration. Infiltrated glioma cells persist in the brain post-resection where they interact with glial cells and experience interstitial fluid flow. We use patient-derived glioma stem cells and human glial cells (i.

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Background And Objectives: Older adults (≥65 years) are living longer with complex health needs and wish to remain at home as their care needs change. We aimed to determine which factors influence older persons' transitions from home living to facility-based care (FBC) settings such as long-term care facilities or assisted living.

Research Design And Methods: Through a scoping review of 7 databases, we considered all academic literature examining factors influencing transitions from home living to FBC.

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A growing body of research has suggested that high levels of family functioning-often measured as positive parent-child communication and low levels of parental stress-are associated with stronger cognitive development, higher levels of school engagement, and more successful peer relations as youth age. The COVID-19 pandemic has brought tremendous disruption to various aspects of daily life, especially for parents of young children, ages 3-5, who face isolation, disconnection, and unprecedented changes to how they engage and socialize. Fortunately, both youth and parent brains are plastic and receptive to change.

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Article Synopsis
  • Chemotherapy, particularly platinums, has been found to promote changes in lymphatic systems that could unintentionally enhance cancer malignancy instead of just inhibiting tumor growth.
  • In experiments with mouse models and human patients, platinums induced systemic lymphangiogenesis, which is the formation of new lymphatic vessels, and this effect was shown to be dose-dependent and long-lasting.
  • The study suggests that blocking these lymphatic changes with VEGFR3 inhibitors could improve treatment outcomes, advocating for adjustments in cancer therapies that involve platinum-based drugs.
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Background: Long-term care (LTC) residents frequently experience transitions in the location of more advanced care delivery, including receiving emergency department (ED) care. In this proof-of-concept study, we aimed to determine if we could identify measures in quality of care across transitions from LTC to the ED, via emergency medical services and back, by applying Institute of Medicine (IOM) Quality of Care Domains to an existing dataset.

Methods: In the Older Persons' Transitions in Care (OPTIC) study, we collected information on residents' transitions in two Western Canadian cities.

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