Corrigendum: Epidemiology, risk factors and outcomes of prolonged mechanical ventilation with different cut-points in a PICU.

[This corrects the article DOI: 10.3389/fped.2023.

Epidemiology, risk factors and outcomes of prolonged mechanical ventilation with different cut-points in a PICU.

Background: A consensus on the definition of prolonged mechanical ventilation (PMV) for children does not exist. There is still lack of published work presenting the epidemiology, risk factors and outcomes at different cut-points for PMV patients. These are important for planning the goals of treatment and counseling of the prognosis for patient families.

Comparison of piperacillin plasma concentrations in a prospective randomised trial of extended infusion versus intermittent bolus of piperacillin/tazobactam in paediatric patients.

Objectives: To be effective, piperacillin/tazobactam (PTZ) unbound plasma levels need to be above the minimum inhibitory concentration (MIC) at least 50% of the time between dosing intervals (50% fT). This study aimed to compare the plasma piperacillin concentrations at the mid-dosing intervals (C, 50% fT) and the proportion of patients achieving 50% fT between extended infusion (EI) and intermittent bolus (IB) methods in children.

Methods: A prospective, randomised trial of EI versus IB of PTZ was conducted in children aged 1 month to 18 years.