[Possible Choice of New Oral Anticoagulants With Non-Valvular Atrial Fibrillation: a Review of Meta-Analyzes].

This review presents the results of a meta-analysis including data from all four studies of new oral anticoagulants for the prevention of stroke or systemic embolism in patients with non-valvular atrial fibrillation. It was found that all of the drugs had a favorable risk profile/efficiency, and provides a significant reduction in the incidence of stroke, intracranial hemorrhage and mortality. This increases the number of gastrointestinal bleeding.

[Cost-effectiveness of apixaban compared to other new oral anticoagulants in patients with non-valvular atrial fibrillation].

Background: Atrial fibrillation is associated with development of thromboembolic events. New oral anticoagulants (apixaban, rivaroxaban and dabigatran) are recommended for antithrombotic therapy in patients with non-valvular atrial fibrillation (NVAF) with moderate and high risk of stroke.

Objectives: The objective of this study was to evaluate the cost-effectiveness ratio of apixaban compared to dabigatran and rivaroxaban in patients with NVAF from the Russian Federation national health care system perspective.

[Asymptomatic ventricular pre-excitation in children: a 17 year follow-up study].

Results of long term clinic-electrophysiological follow-up of a large group of children with Wolf-Parkinson-White (WPW) phenomenon are present. From 1993 to 2011 we examined 176 children - 117 boys (66,5%) and 59 girls (33,5%) - with manifesting type of WPW. Age at first examination was 12.

[Prevalence and clinical features of atrial fibrillation in the north-west of the Russian Federation].

Incidence and prevalence of atrial fibrillation (AF) are analysed for the period from 1980 to 2004. They are shown to increase 5 and 6-fold respectively in the north-western region of Russia. Prevalence of AF in men increased 10-fold and in women 4-fold.

[Genetic polymorphism and risk of arterial thrombosis in patients with atrial fibrillation].

This study revealed the importance of 6 genetic determinants (accounting for predisposition to thrombophilia) as risk factors of thromboembolic stroke in patients with atrial fibrillation (AF). The occurrence of A-allele of FGB gene of patients with complicated form of AF was shown to be significantly higher compared with controls. Carriage of FGB-455A, grade II mitral regurgitation, and AF longer than 48 hours are assumed to be independent predictors of thromboembolic stroke.

[Alternative approaches to treatment of paroxysmal atrial fibrillation].

Choice of the optimal antiarrhythmic therapy still remains a challenge. Most frequently, antiarrhythmic agents used to reestablish and maintain sinus rhythm do not provide satisfactory clinical effect. Understanding electrophysiological mechanisms of initiation and maintenance of atrial fibrillation is the best way to develop optimal therapeutic approaches.

[Microbiological degradation of benz(a)pyrene in soil].

Several microbial clones that could grow on the benz(a)pyrene medium were identified from the soils contaminated with petroleum products. It was shown that benz(a)pyrene could be degraded by the obtained cultures that selectively utilized the carcinogenic molecules of benz(a)pyrene in the presence of other sources of carbohydrate. The authors give recommendations on the biodestruction of benz(a)pyrene and other polycyclic aromatic hydrocarbons under natural conditions in order to improve the oncoecological situation.

['Uninterrupted' anterograde atrioventricular excitation conduction in patients with paroxysmal reciprocal atrioventricular nodal tachycardias].

Different variants of anterograde atrioventricular conduction of excitation were distinguished basing on data obtained from 150 patients with paroxysmal reciprocal atrioventricular nodal tachycardias. Excitation conduction during programmed and accelerating atrial transesophageal pacing allowed to assess characteristics of excitation conduction along fast and slow conduction pathways in atrioventricular node. Some parameters were suggested that allowed to predict possibility of detection of different variants of anterograde atrioventricular conduction of excitation.

[Identification of slow anterograde conduction of excitation in patients with paroxysmal reciprocal atrioventricular nodal tachycardia].

Basing on results of examination of a cohort of patients with typical paroxysmal reciprocal atrioventricular tachycardia a group of patients with continuous curve of anterograde conduction was distinguished. The use of incremental doses of adenosine triphosphate (ATP) during transesophageal atrial pacing allowed in some cases to identify slow conduction through atrioventricular node and to initiate paroxysmal nodal tachycardia. The dose of ATP causing conduction block over fast pathway depended on the duration of effective refractory period.

[Electrophysiological criteria for efficacy of different antiarrhythmics classes in patients with paroxysmal reciprocal atrioventricular nodal tachycardia].

Clinical and electrophysiological studies of 510 patients with different paroxysmal reciprocal atrioventricular nodal tachycardias identified criteria for resistance of paroxysmal nodal tachycardia. Examination of changes in major electrophysiological parameters due to different antiarrhythmics established the specific features of their electrophysiological action and thereof criteria for the efficacy of antiarrhythmic therapy.