Long-range dispersion C coefficient for SF dimer: Experimental and theoretical study.

The long-range dispersion C coefficient for the SF dimer is experimentally measured using a technique that uses the expansion of a supersonic pulse jet into a vacuum. A dynamic model of the jet enables us to correlate the position of the maximal peak in the time-of-flight spectrum with the initial conditions of the experiment and the parameters of the intermolecular interaction potential. Due to the low temperature of the jet target, the C coefficient can be extracted directly from the experimental results.

Organization of human interferon gamma-heparin complexes from solution properties and hydrodynamics.

Heparan sulfate (HS) recognizes a variety of proteins, one of which is the pleiotropic cytokine IFN-gamma, and as such modulates many biological processes. IFN-gamma is a homodimer with a well-defined core and two flexible C-termini that constitute HS binding domains. We show here using molecular modeling that an extended IFN-gamma structure overlaps a HS fragment of 16 disaccharides (16 nm).

Conformation of heparin studied with macromolecular hydrodynamic methods and X-ray scattering.

The hydrodynamic characteristics of heparin fractions in a 0.2 M NaCl solution have been determined. Experimental values varied over the following ranges: the sedimentation coefficient (at 20.