[Silent Myocardial Ischemia as a Result of Cardiac Autonomic Neuropathy].

Aim: to verify the effect of vegetative nervous system on the silent myocardial ischemia.

Materials And Methods: We included in this study 56 patients with functional class II-III effort angina (22 men and 34 women, age 45-49 years) with silent myocardial ischemia (SMI). Examination included 24hour blood pressure and ECG monitoring.

[The interrelationship of indices of hemocysteine and genetic polymorphisms conditioning disorders of folates metabolism in healthy population].

The study was carried out to investigate relationship of the level of homocysteine and genetic polymorphisms conditioning disorders of metabolism of folates in healthy population and of various age and gender groups. The study covered 168 donors: 98 males and 70 females. Two gender groups were singled out and in each of them age groups: 18-31, 32-45 and 46-60 years old.

[Myocardial revascularization in correction of electrical instability of the heart in patients with postinfarction cardiosclerosis].

We have assessed parameters of myocardial electrical instability in patients with postinfarction atherosclerosis before and in one year after coronary bypass surgery. Inclusion criteria were history of myocardial infarction, surgical myocardial revascularization between 1 and 2 years before; stable course of coronary heart disease during previous month; preserved ejection fraction ( more or equal 50%), stable sinus rhythm. Heterogeneity of myocardial electrophysiological properties has diminished after coronary bypass surgery due to improvement of coronary perfusion and restoration of function of ischemic myocardium.

[Clinical- functional assessment of organoprotective efficacy of enalapril and telmisartan in patients with arterial hypertension].

Effect of enalapril and telmisartan on hemodynamic indices, structural-functional parameters of the left ventricle, and vasomotor function of arterial endothelium was studied in 49 patients (mean age 48.3+/-3.2 years) with 1-2 degree arterial hypertension (AH) and abnormal relaxation type of left ventricular diastolic dysfunction.

[Clinical and functional assessment of electric heart instability in patients with painless myocardial ischemia].

Markers of electric myocardial instability were studied in 82 patients during painless episodes of coronary heart disease (CHD). Clinical examination was supplemented by 12-lead ECG, 24-hour ECG monitoring, functional tests, echocardiography, signal-averaged ECG, recording of LVP, analysis of cardiac rhythm variability, and assessment of ventricular repolarization time. It is concluded that a combination of 24-hr ECG monitoring and functional tests (veloergometer) is indispensable for diagnostics of CHD and the evaluation of the patient"s condition.

[Clinical functional assessment of electric cardiac instability in diastolic dysfunction of the left ventricle in patients with coronary heart disease].

Aim: To study parameters characterizing electric myocardial unstability in coronary heart disease (CHD) patients with different variants of diastolic dysfunction (DD) of the left ventricle (LV).

Material And Methods: The study included 86 outpatients (26 females, 60 males, mean age 57.3 +/- 5.

[The clinical and functional evaluation of cardiac electrical instability in patients with silent myocardial ischemia].

Aim: To study markers of myocardial electrical instability in patients with coronary heart disease (CHD) during silent myocardial ischemic episodes.

Subjects And Methods: Eighty-two patients with stable CHD (mean age 62.6 +/- 5.

[Arterial hypertension and type 2 diabetes mellitus: clinical evaluation of hemodynamic characteristics, possibility of correction].

The study was designed to evaluate effect of enalapril and telmisartan on hemodynamic characteristics and diastolic function (DF) of left ventricle (LV) in patients with type 2 diabetes and arterial hypertension (AH). It included 64 patients aged 54.3 +/- 5.

[Significanvce of dysfunction of vascular endothelium for the evaluation of episodes of myocardial ischemia in type 2 diabetes mellitus].

The objective of this study was to evaluate the vasculomotor function of endothelium in patients with type 2 diabetes mellitus and assess the role of its functional state in the development of ischemic episodes. A total of 93 patients (52 men and 41 women) of the mean age of 58.3+-4.

[The clinical and hemodynamic efficacy of telmisartan and enalapril in the treatment of arterial hypertension in patients with type 2 diabetes mellitus].

Aim: To study the effects of enalapril and telmisartan on hemodynamic parameters and diastolic function (DF) of the left ventricle (LV) in patients with type 2 diabetes mellitus (DM) concurrent with arterial hypertension (AH).

Subjects And Methods: The study included 64 patients (mean age 54.3 +/- 5.

[Coraxan and atenolol: similarities and differences in correction of clinical and functional indices in therapy of patients with coronary heart disease].

The aim of the study was to estimate clinical and functional indices under stable course of coronary heart disease (CHD) against the background of therapy with coraxan and atenolol. 95 patients (70 males and 29 females, average age 52.3 +/- 4.

[Comprehensive assessment of ischemic episodes and vasomotor function of vascular endothelium in patients with type II diabetes mellitus].

Value of functional state of endothelium in assessment of episodes of ischemia was studied in 93 patients (52 men and 41 women, mean age 58.3 +/- 4.8 years) divided into 2 groups.

[Clinical efficacy of ivabradin and nebivolol addition in combined treatment of ischemic heart disease patients with left ventricular dysfunction].

Aim: To assess ivabradin and nebivolol efficacy in combined treatment of ischemic heart disease patients with chronic heart failure (CHF) of functional class (FC) II-III by NYHA, impact of these drugs on quality of life, circadian indices of myocardial ischemia (CMI), left ventricular (LV) contractility.

Material And Methods: A total of 92 patients with CHF of FC II-III (mean age 57.3 +/- 4.

[Clinicofunctional evaluation of ischemic episodes and vascular endothelium in patients with type 2 diabetes].

The aim of the investigation was to study the significance of the functional condition of endothelium for the evaluation of ischemic episodes in patients with type 2 diabetes mellitus (DM2). Ninety-three patients (52 men; 41 women; mean age 58.3+/-4.

[Ventricular arrhythmias and cardiac late potentials inpatients with acute coronary syndrome after reperfusion therapy].

The prognostic value of ventricular late potentials (VLP) and the character of rhythm disturbance were studied in 64 patients with acute coronary syndrome. 8 hours after system thrombolysis procedure VLP rate increased from 68.6% up to 85.

[Anti-arrhythmic therapy: diagnostic possibilities of signal-averaged electrocardiography and heart rate variability].

Effects of monotherapy with class IC, II and III antiarrhythmic drugs on parameters of signal averaged (SA) ECG and heart rate variability were studied in 88 patients (mean age 45.6+/-7.8 years).

[Hemodynamics, electrophysiological parameters of the heart and differential therapy of attacks of atrial fibrillation in patients with subclinical thyroid dysfunction].

Thirty patients with subclinical thyrotoxicosis and 32 with subclinical hypothyroidism with attacks of atrial fibrillation were investigated. At levels of thyroid-stimulating hormone below 0.1 or above 10.

[Thyroid hormones effects on hemodynamic and electrophysiological indices of heart performance and efficiency of antiarrhythmic drugs in paroxysms of cardiac fibrillation in patients with coronary heart disease].

The article provides the results of thyrotropic hormones (TH) influence on spontaneous paroxysms of cardiac fibrillation (CFP), central hemodynamics, electrophysiology (EP) of the heart and effectiveness of antiarrhythmic drugs (AAD) in patients with coronary heart disease (CHD). It is shown that in CFP patients TH should be evaluated in sinus rhythm and in arrhythmia. Fluctuations in TH contribute to CFP.

[Differential diagnosis of infectious and non-infectious thrombotic endocarditis].

The aim of the study was analysis of clinical and laboratory markers of non-infectious thrombotic endocarditis (NITE) to facilitate differential diagnosis with infectious endocarditis (IE). 20 NITE patients (8 males and 12 females, mean age 32.3 years) were included in the trial.

[Diagnostic value of late ventricular potentials in patients with painless myocardial ischemia].

The study of peculiarities of late ventricular potentials (LVPs) registration in patients with painless myocardial ischemia (PIMI) and painful myocardial ischemia (PMI) in unstable or stable running of ischemic heart disease (IHD) enrolled 113 patients (88 males and 25 females, mean age 52.3 +/- 6.8 years).