Finding potential inhibitors from phytochemicals against nucleoprotein of crimean congo fever virus using in silico approach.

The Crimean Congo virus has been reported to be a part of the spherical RNA-enveloped viruses from the Bunyaviridae family. Crimean Congo fever (CCHF) is a fatal disease with having fatality rate of up to 40%. It is declared endemic by the World Health Organization.

Zinc-lysine and iron-lysine mitigate chromium toxicity in pearl millet (Pennisetum glaucum) through modulating photosynthetic and antioxidant system and inhibiting chromium uptake and translocation.

Chromium (Cr) is an ever-present abiotic stress that negatively affects crop cultivation and production worldwide. High rhizospheric Cr concentrations inhibit nutrients uptake and their translocation to aboveground parts, thus can affect the growth and development of crop plants. This experiment was designed to evaluate the effects of sole and combined zinc-lysine and iron-lysine applications on photosynthetic efficacy, antioxidative defense, oxidative stress, and nutrient uptake and translocation under Cr stress.

Comparative analysis of heavy metals toxicity in drinking water of selected industrial zones in Gujranwala, Pakistan.

Heavy metal contamination of drinking water, primarily driven by industrial activities, represents a critical challenge, with implications for human health and environmental safety. Gujranwala is an industrial and thickly populated city. The current study aimed to assess and compare heavy metal contamination levels in drinking water from five industrial areas and evaluate their potential impacts on human health.

A proficient approach for the classification of Alzheimer's disease using a hybridization of machine learning and deep learning.

Alzheimer's disease (AD) is a neurodegenerative disorder. It causes progressive degeneration of the nervous system, affecting the cognitive ability of the human brain. Over the past two decades, neuroimaging data from Magnetic Resonance Imaging (MRI) scans has been increasingly used in the study of brain pathology related to the birth and growth of AD.

Structural investigation of erdafitinib, an anticancer drug, with ctDNA: A spectroscopic and computational study.

The interaction of drugs with DNA is crucial for understanding their mechanism of action, particularly in the context of gene expression regulation. Erdafitinib (EDB), a pan-FGFR (fibroblast growth factor receptor) inhibitor approved by the FDA, is a potent anticancer agent used primarily in the treatment of urothelial carcinoma. In this study, the binding interaction between EDB and calf thymus DNA (ctDNA) was assessed using molecular docking, UV-absorption spectroscopy, fluorescence spectroscopy, and circular dichroism (CD) spectroscopy.

Domino Partial Heart Transplantation.

Heart valve replacement in pediatric cardiothoracic surgery poses problems because conventional heart valve implants do not have the ability to grow. This mandates serial reoperations for implant exchanges until an adult size implant can fit. Partial heart transplantation eliminates these reoperations because the transplanted valves grow.

DeBo: Contrast enhancement for image registration using binary differential evolution and bat optimization.

Image registration has demonstrated its significance as an essential tool for target recognition, classification, tracking, and damage assessment during natural catastrophes. The image registration process relies on the identification of numerous reliable features; thus, low resolutions, poor lighting conditions, and low image contrast substantially diminish the number of dependable features available for registration. Contrast stretching enhances image quality, facilitating the object detection process.

Performance and Stability of Corundum-type In2O3 Catalyst for Carbon Dioxide Hydrogenation to Methanol.

Carbon dioxide hydrogenation to methanol is a key chemical reaction to store energy in chemical bonds, using carbon dioxide as an energy sink. Indium oxide is amongst the most promising candidates for replacing the copper and zinc oxide catalyst, which is industrially applied for syngas mixtures but less idoneous for educts with carbon dioxide due to instability reasons. The polymorph of indium oxide and the operating conditions remain to be optimized for optimal and stable performance.

Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.

Aims And Objectives: Hepatitis C virus (HCV) infection is a significant risk factor for the development of hepatocellular carcinoma (HCC). Serum-derived circular RNAs (circRNAs) play several crucial roles in HCV and HCC. They represent a promising area of research for improving the diagnosis and understanding the mechanisms of HCV-HCC.

Awareness and Practices of Menstrual Hygiene Among Rural Adolescent Schoolgirls in Lahore, Pakistan: A Cross-Sectional Study.

Background Empowering adolescent girls with accurate data, a supportive environment, and access to resources is crucial for promoting their dignity and educational success, thereby enabling gender equity and social development in rural communities. Aim This research aims to assess the knowledge and practices of menstrual hygiene among adolescent girls in schools within the rural community of Lahore, Pakistan. Methodology This research employed a quantitative, cross-sectional design, with a survey conducted among 108 participants in Lakhodair Sharif Bakra Mandi, Lahore, Pakistan.

Innovative CO-NBs-assisted ultrasonication for the phytochemical extraction of peanut (Arachis hypoga) shells: Synthesis and characterization of CO-nanobubbles.

This study was designed to obtain the maximum extraction yield of peanut shell (PS) polyphenols using a novel carbon dioxide nanobubbles (CO-NBs) assisted ultrasonic extraction method. CO-NBs were generated in distilled water with a self-developed high-pressure nano-jet homogenization method and characterized by size, zeta potential and transmission electron microscopy (TEM). The obtained nanobubble's mean size and zeta potential were 229.

Deployment of a Machine Learning Algorithm in a Real-World Cohort for Quality Control Monitoring of Human Epidermal Growth Factor-2-Stained Clinical Specimens in Breast Cancer.

Context.—: Precise determination of biomarker status is necessary for clinical trial enrollment and endpoint analyses, as well as for optimal treatment determination in real-world practice. However, variabilities may be introduced into this process due to the processing of clinical specimens by different laboratories and assessment by distinct pathologists.

Aggressive Versus Moderate Fluid Replacement for Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis.

Background: A conservative strategy is the primary modality of treatment for acute pancreatitis of which fluid replacement is an important component. Since the results regarding early aggressive versus moderate fluid replenishment for acute pancreatitis are inconsistent, we sought to compare outcomes between the two resuscitation strategies in our meta-analysis.

Methods: We searched MEDLINE (PubMed), Embase, the Cochrane Library, and ClinicalTrials.

Rectal Cancer Surgery in a District Hospital: Our Experience.

Introduction Rectal cancer forms a significant proportion of newly diagnosed colorectal cancer. Treatment of rectal cancer is multi-modal, but surgery remains the cornerstone of treatment of rectal cancer and has undergone significant changes in the last three decades. The advent of minimally invasive techniques has revolutionised the landscape of surgery of the rectum.

Diagnostic Accuracy of the Modified Alvarado Score and Serum C-reactive Protein in Acute Appendicitis.

Background The Alvarado score is a diagnostic tool to stratify patients on the likelihood of acute appendicitis based on signs, symptoms, and laboratory values. The validity of this score as compared to other diagnostic measures for acute appendicitis is questionable. The current study addresses the use of a modified Alvarado score (MAS) in conjunction with the widely used acute phase reactant biomarker serum C-reactive protein (CRP) for diagnostic accuracy.

Comparative Neurodynamic Analysis of Spinal Energy Enhancement in Experienced Yoga Practitioners Using Various Breathing Techniques.

Introduction:  Yoga practices emphasize spinal energy's role in physical, mental, and spiritual well-being, suggesting specific techniques that can enhance energy flow along the spine. Modern research aims to validate these claims and understand the mechanisms behind these effects, potentially integrating them into contemporary healthcare models. This study explores the relationship between yoga breathing techniques, spinal energy dynamics, and health based on yoga philosophy and bioenergetics.

Evaluation of Antimicrobial Peptides in Saliva as Potential Therapeutic Agents Against Oral Pathogens in Pakistan.

Background: Maintaining optimal oral health is essential for overall well-being; however, conditions such as dental caries and gingivitis remain prevalent in Pakistan and are further worsened by increasing antibiotic resistance.

Objective: To evaluate the antimicrobial properties of salivary peptides as potential therapeutic agents against common oral pathogens in Pakistan.

Methodology: A one-year cross-sectional study was conducted in Lahore, Pakistan, at Sharif Medical and Dental College and Akhter Saeed Medical and Dental College, involving 384 participants aged 18-65 years.

Standardizing social determinants of health data: a proposal for a comprehensive screening tool to address health equity a systematic review.

Social determinants of health (SDoH) significantly impacts health outcomes and disparities. While the Centers for Medicare and Medicaid Services has mandated hospitals to collect standardized SDoH data, existing tools lack key elements. This systematic review identified 78 studies and 20 screening tools addressing various SDoH domains.

Synthesis and mechanistic studies of 4-aminoquinoline-Isatin molecular hybrids and Schiff's bases as promising antimicrobial agents.

In this investigation, to determine their potential as specific antibacterial agents, Schiff's bases (LT-SB1-23 and SB1-SB12) and novel quinoline-isatin hybrids were subjected to microbiological testing. The in-vitro screening against bacterial strains (Escherichia coli, Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi) exhibited their antibacterial potential with many of the compounds showing inhibition range of 90-100 % at 200 μg/mL, against most of the tested strains. The MIC values of some of the compounds showed good antibacterial efficacy with values ranging from 32 to 128 μg/mL.

Incidence of endosymbiont bacteria Wolbachia in cowpea weevil Callosobruchus maculatus Fabricius (Coleoptera, Chrysomelidae).

This study focuses on the cowpea weevil, Callosobruchus maculatus, a globally distributed grain pest that affects cereals and pulses. Using chemicals to store grains can harm pest control and pose risks to consumers and the environment. The facultative intracellular symbiont bacteria Wolbachia can affect host's reproductive capacities in a variety of ways, which makes it useful in the management of pests such as C.