Publications by authors named "Tasneem R Abdel-Karim"
The instant blood-mediated inflammatory response (IBMIR) causes islet loss and compromises diabetes outcomes after total pancreatectomy with islet autotransplant (TPIAT). We previously reported a possible benefit of etanercept in maintaining insulin secretion 3 months post-TPIAT. Here, we report 2-year diabetes outcomes and peri-operative inflammatory profiles from a randomized trial of etanercept and alpha-1 antitrypsin (A1AT) in TPIAT.
View Article and Find Full Text PDFBackground: In total pancreatectomy with islet auto-transplantation, successful diabetes outcomes are limited by islet loss from the instant blood mediated inflammatory response. We hypothesized that blockade of the inflammatory response with either etanercept or alpha-1-antitrypsin would improve islet function and insulin independence.
Methods: We randomized 43 participants to receive A1AT (90 mg/kg x 6 doses, n = 13), or etanercept (50 mg then 25 mg x 5 doses, n = 14), or standard care (n = 16), aiming to reduce detrimental effects of innate inflammation on early islet survival.
Article Synopsis
- The study aims to analyze various aspects of type 2 diabetes in individuals under 18, including its epidemiology, clinical signs, and biochemical markers.
- From 2018 to 2020, researchers evaluated 104 young patients, revealing a higher prevalence and incidence of type 2 diabetes, primarily affecting Qatari males, with a significant correlation to obesity and maternal gestational diabetes.
- The findings emphasize the need for preventive measures targeting childhood obesity and maternal health to mitigate future health complications associated with early-onset type 2 diabetes in Qatar.
Purpose: The purpose of the study was to delineate parental concept of road safety in the state of Qatar, integrate parental thoughts and ideas into public safety, and share our data with authorities to assist in implementing campaigns against speeding in a country with a high rate of motor vehicle accidents.
Methods: A cross-sectional prospective study was conducted at Hamad Medical Corporation (HMC), the only tertiary care and academic hospital in the state of Qatar. Parents of children younger than 18 years of age and residents of the State of Qatar were offered an interview survey.