Examining mental health engagement among veterans diagnosed with serious mental illness.

Engagement in psychosocial mental health services has been found to support and facilitate the process of recovery in individuals with serious mental illness. However, many individuals eligible for these services are not receiving them. Presently, little is known about the factors that contribute to treatment engagement.

A controlled trial of adaptive disclosure-enhanced to improve functioning and treat posttraumatic stress disorder.

Objective: This is a randomized controlled trial (NCT03056157) of an enhanced adaptive disclosure (AD) psychotherapy compared to present-centered therapy (PCT; each 12 sessions) in 174 veterans with posttraumatic stress disorder (PTSD) related to traumatic loss (TL) and moral injury (MI). AD employs different strategies for different trauma types. AD-Enhanced (AD-E) uses letter writing (e.

A Computational Framework for EEG Causal Oscillatory Connectivity.

Here we advance a new approach for measuring EEG causal oscillatory connectivity, capitalizing on recent advances in causal discovery analysis for skewed time series data and in spectral parameterization of time-frequency (TF) data. We first parameterize EEG TF data into separate oscillatory and aperiodic components. We then measure causal interactions between separated oscillatory data with the recently proposed causal connectivity method Greedy Adjacencies and Non-Gaussian Orientations (GANGO).

Reconsidering research exclusion for serious mental illness: Ethical principles, current status, and recommendations.

Background: Historically, individuals managing serious mental illness (SMI) have often been excluded from research, typically because of concern that these individuals may not be able to understand and provide truly informed consent. As treatment has improved, the assumption that individuals managing SMI may not be capable of consent needs to be re-examined. Systematic exclusion from research may limit empirically tested treatments available for people managing SMI, and may contribute to the health care disparities seen in this population.

Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia.

Background: Thalamic projections to the prefrontal cortex (PFC) are critical for cognition, and disruptions in these circuits are thought to underlie the pathophysiology of schizophrenia. Cognitive remediation (REM) is a behavioral intervention that holds promise for improving cognition and functioning in schizophrenia, however the extent to which it affects thalamo-prefrontal connections has not been researched. This study sought to determine whether patients with schizophrenia who undergo a placebo-controlled trial of REM show increased functional connectivity between the thalamus and PFC, and whether these changes correspond to improvements in cognition.

Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: triple-blind trial.

Patients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.To use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).Twenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST.

Effects of the Indianapolis Vocational Intervention Program (IVIP) on defeatist beliefs, work motivation, and work outcomes in serious mental illness.

Defeatist beliefs and amotivation are prominent obstacles in vocational rehabilitation for people with serious mental illnesses (SMI). The CBT-based Indianapolis Vocational Intervention Program (IVIP) was specifically designed to reduce defeatist beliefs related to work functioning. In the current study, we examined the impact of IVIP on defeatist beliefs and motivation for work, hypothesizing that IVIP would be associated with a reduction in defeatist beliefs and greater motivation for work.

Inpatient utilization before and after implementation of psychosocial rehabilitation programs: analysis of cost reductions.

Research on psychosocial rehabilitation (PSR) interventions generally indicates that these approaches are effective in facilitating improved functioning for persons with serious mental illness (SMI; schizophrenia, schizoaffective disorder, bipolar disorder, and other psychotic disorders). In this quasi-experimental study, we assessed the effectiveness of PSR interventions through a records review of 311 veterans who received outpatient services for SMI. From 2002 to 2008, a midwestern VA Medical Center implemented a number of PSR interventions.

Attribution biases in schizophrenia: relationship to clinical and functional impairments.

Background: Patients with schizophrenia exhibit impairment in their ability to accurately recognize facial emotions in others, and the severity of this emotion perception deficit has been associated with poorer functioning. However, the mechanisms underlying facial emotion perception deficits are poorly understood. There is evidence to suggest that patients, particularly those with certain positive symptoms, may misinterpret other people's facial expressions as having an overly negative valence.

Computerized measurement of negative symptoms in schizophrenia.

Accurate measurement of negative symptoms is crucial for understanding and treating schizophrenia. However, current measurement strategies are reliant on subjective symptom rating scales, which often have psychometric and practical limitations. Computerized analysis of patients' speech offers a sophisticated and objective means of evaluating negative symptoms.

Attentional dysfunction, social perception, and social competence: what is the nature of the relationship?

The aim of this study was to examine the nature of the relationship between attentional dysfunction and social competence deficits in patients with schizophrenia. Attentional functioning, social perception, and social competence were assessed in 56 inpatients. Measures of vigilance and span of apprehension were administered to assess attentional functioning.

Neurocognitive and social cognitive correlates of formal thought disorder in schizophrenia patients.

The neurocognitive and social cognitive correlates of two types of formal thought disorder (i.e., bizarre-idiosyncratic and concrete thinking) were examined in 47 stable outpatients with schizophrenia.

Diminished emotionality and social functioning in schizophrenia.

There is indirect evidence to suggest that a subgroup of patients with schizophrenia exhibit a diminished capacity to experience both positive and negative emotions. To date however, no studies have focused specifically on this diminished emotionality (DE). The main objective of the present project was to determine whether patients with self-reported DE differed from other patients in level of social functioning, physical and social anhedonia, and negative/deficit symptoms.

Internal source monitoring and communication disturbance in patients with schizophrenia.

Background: This study examined the relationship between internal source monitoring and disordered speech in patients with schizophrenia or schizoaffective disorder. It was predicted that internal source monitoring would relate specifically to one type of communication disturbance, the missing information reference.

Method: Immediate, working, and internal source memory were assessed in 47 out-patients diagnosed with schizophrenia or schizoaffective disorder.

Internal source monitoring and thought disorder in schizophrenia.

A new task was developed to examine source monitoring in 52 patients with schizophrenia. Patients and nonpsychiatric controls were not found to differ on recognition memory, source discrimination, or attribution bias when the between group difference in IQ was controlled. However, among patients, source discrimination was significantly related to severity of thought disorder.

Stress and arousability in schizophrenia.

This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress during the speech tasks, were examined both between and within groups.

Self-reported stress and the deficit syndrome of schizophrenia.

GENERALLY speaking, schizophrenia is not associated with diminished positive and negative emotions. Even patients with negative symptoms such as blunted affect have generally not differed in their levels of self-reported emotionality compared to patients without negative symptoms. However, there is evidence to suggest that a subgroup of patients with negative symptoms, those with the deficit syndrome, have a diminished capacity to experience positive and negative emotions.

Stability of formal thought disorder and referential communication disturbances in schizophrenia.

This study examined the degree to which different types of communication disturbances in the speech of 48 schizophrenia patients and 28 controls were variable and state related versus stable and traitlike. Clinically rated formal thought disorder and 5 types of referential disturbance showed substantial stability within participants over time. The sixth type of referential disturbance, the vague reference, was not stable over time.