Publications by authors named "Tasfia Zahin"
A tandem repeat is a sequence of nucleotides that occurs as multiple contiguous and near-identical copies positioned next to each other. These repeats play critical roles in genetic diversity, gene regulation, and are strongly linked to various neurological and developmental disorders. While several methods exist for detecting tandem repeats, they often exhibit low accuracy when the repeat unit length increases or the number of copies is low.
View Article and Find Full Text PDFCircular RNA (circRNA) is a class of RNA molecules that forms a closed loop with their 5' and 3' ends covalently bonded. CircRNAs are known to be more stable than linear RNAs, have distinct properties and functions, and are promising biomarkers. Existing methods for assembling circRNAs heavily rely on the annotated transcriptomes, hence exhibiting unsatisfactory accuracy without a high-quality transcriptome.
View Article and Find Full Text PDFArticle Synopsis
- Circular RNA (circRNA) is a unique type of RNA that forms a stable closed loop and has significant biological functions that were previously underestimated due to biases in RNA sequencing techniques.
- The new algorithm, TERRACE, addresses the challenge of assembling circRNAs from RNA-seq data by using a splice graph to efficiently identify "bridging" paths and improves detection of back-spliced reads missed by other methods.
- TERRACE outperforms existing circRNA detection methods in sensitivity and precision, particularly in cases where annotated transcriptomes are unavailable, making it a major advancement in the field.