Publications by authors named "Tasanarong A"
Article Synopsis
- This study compares the effectiveness of cannabis cream versus a placebo for relieving itching in patients with chronic kidney disease (CKD) undergoing hemodialysis.
- Conducted as a double-blind randomized controlled trial with 60 participants, the primary measure of success was the itching intensity score (WI-NRS) after 4 weeks.
- Results showed a significant reduction in itching for the cannabis group compared to placebo at 4 weeks, but the study's small sample size and other limitations make it difficult to draw broad conclusions.
Article Synopsis
- The Kheaw-Hom (KH) remedy, a traditional Thai medicine known for treating fever and inflammation in children, has not previously been studied for its anti-inflammatory effects or bioactive compounds.
- This study aimed to assess the in vitro and in vivo anti-inflammatory properties of KH remedy and its key compound, ethyl p-methoxycinnamate (EPMC), while investigating the connection between flavor and ethnopharmacological functions based on traditional Thai medicine theory.
- Results revealed that a specific preparation of KH (KHP-h) exhibited the highest EPMC content and effectively reduced inflammatory markers in both cell cultures and in vivo experiments, indicating its potential as a therapeutic anti-inflammatory agent.
Article Synopsis
- * Traditional diagnosis of kidney rejection and dysfunction relies on invasive biopsies, which can be performed too late for effective treatment.
- * Non-invasive biomarkers like donor-derived cell-free DNA and microRNAs show promise for better monitoring and management of kidney transplants, though they have some limitations.
Article Synopsis
- In angiotensin II (Ang II)-dependent hypertension, Ang II activates receptors that cause renal vasoconstriction, leading to kidney damage and inflammation.
- Increased arterial pressure triggers ATP release, which constricts afferent arterioles through another receptor, highlighting a dual mechanism of resistance in the kidney.
- The interaction between these receptors suggests they might share signaling pathways, presenting potential targets for therapies aimed at protecting kidney function in hypertension.
Article Synopsis
- The Prasachandaeng (PSD) remedy, used in Thai traditional medicine for fever and cancer treatment, was studied for its chemical composition and potential anti-cancer properties, as no scientific research had previously documented these effects.* -
- Researchers isolated compounds from D. cochinchinensis and assessed the remedy's cytotoxicity against liver and bile duct cancer cell lines compared to a non-cancerous cell line, utilizing HPLC for quality control and ELISA for anti-inflammatory measurements.* -
- Findings revealed that PSD showed significant cytotoxic effects against the HepG2 and KKU-M156 cancer cell lines, with some isolated compounds demonstrating moderate cytotoxicity, indicating potential use in cancer treatment alongside traditional methods.*
Article Synopsis
- A meta-analysis was conducted to better understand the link between specific genetic variations (SNPs) and kidney transplant rejection by studying multiple articles and focusing on transplant patients who either rejected or accepted their grafts.
- The analysis evaluated the risk associated with four specific SNPs and showed differing outcomes based on genetic type and subgroup characteristics, including ethnicity and type of rejection.
- Significant results revealed that one SNP was linked to a lower risk of rejection, while others indicated an increased risk, particularly related to chronic rejection in certain ethnic groups, suggesting these genetic markers could be important for kidney transplant clinical practices.
Article Synopsis
- The Prasachandaeng (PSD) remedy, used in Thailand for centuries to reduce fever, was found to have significant antipyretic effects similar to acetaminophen (ACP) in a study involving rats.
- When examining liver safety, various PSD forms showed no signs of damage, with liver function tests indicating normal levels and less hepatotoxicity compared to ACP.
- Histopathological analysis confirmed these findings, demonstrating that both PSD powder and ethanol extract were effective at lowering fever without harmful effects on liver health over a seven-day period.
Article Synopsis
- - Myopia, especially common among young individuals in Asia, has led to various proposed solutions, one of which is auricular acupoint stimulation (AAS), though results have varied.
- - A meta-analysis of 12 studies assessed the effectiveness of AAS, utilizing odds ratios and confidence intervals to evaluate treatment outcomes and check for bias.
- - The analysis found that AAS significantly benefits myopia control, with treatment groups showing up to a 3.4 times greater effectiveness compared to others, indicating strong, reliable results.
Article Synopsis
- The study investigates the relationship between specific genetic variations (SNPs) in the cannabinoid receptor 1 (CNR1) gene and the risk of alcohol dependence (AD), noting previous inconsistent findings.
- Through a meta-analysis of existing research, the authors identified 14 significant associations from 32 comparisons, highlighting three SNPs (rs1535255, rs2023239, and rs806379) as particularly noteworthy regarding their impact on AD risk.
- Results showed that certain SNPs had a stronger association in Caucasian populations compared to African-American populations, with notable differences in statistical power between various genetic models used for analysis.
Background: Reported associations of the interferon gamma (IFNG) +874T/A (rs2430561) polymorphism with post-kidney transplantation allograft rejection (AR) have been inconsistent, prompting a meta-analysis to obtain more precise estimates.
Methods: Eighteen articles (22 studies) were included in the meta-analysis. Operating on the hypothesis that IFNG rs2430561 either increases or reduces AR risk, we used a genetic model-free approach to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Article Synopsis
- - Intradialytic hypotension (IDH) is a serious complication during hemodialysis, linked to how quickly fluid is removed from patients.
- - A study analyzed 1080 hemodialysis sessions to determine the safest ultrafiltration rates, finding that higher rates significantly increase the risk of IDH.
- - The findings suggest that to prevent IDH, the ultrafiltration rate should be capped at 12 ml/kg/h, and any increases should not surpass 16 ml/kg/h.
Article Synopsis
- Researchers created a kidney transplantation prediction model specifically for Asian populations, addressing a gap since existing models were primarily based on Caucasian data.
- They analyzed data from 6,662 Thai transplant recipients, identifying factors influencing patient and graft survival through statistical methods.
- The new model outperformed a US-based model and can effectively predict outcomes post-transplant, with users able to access it online.
Article Synopsis
- The text indicates a correction has been made to a previously published article.
- The article in question has the Digital Object Identifier (DOI) 10.1155/2013/308130.
- The correction likely addresses errors or issues found in the original publication for accuracy and clarity.
Article Synopsis
- * Out of 644 episodes analyzed, 58.7% showed an early response to treatment, while 18.9% had a delayed response, and 22.3% failed to respond.
- * The results revealed significant differences in average WBC reduction rates among the groups, suggesting that clinicians should pay particular attention to delayed responses and failures to determine whether to continue treatment or remove the catheter.
Article Synopsis
- Acute ischemia-reperfusion (I/R) injury is a leading cause of acute renal failure, characterized by endothelial cell dysfunction and microvascular injury, and EPO has shown protective effects in prior models of I/R injury.
- This study aimed to explore whether EPO administration could protect against renal failure caused by I/R injury in rats by enhancing the mobilization of endothelial progenitor cells (EPCs) and promoting blood vessel formation (neovascularization).
- Results indicated that EPO treatment improved renal function, reduced tubular damage, and increased levels of markers for EPCs and angiogenesis compared to the I/R group without EPO.
Article Synopsis
- A study tested the water extract of Malvastrum coromandelianum (MC) for its ability to lower blood sugar levels in people with type 2 diabetes, building on previous findings in animals that suggested safety and potential effectiveness.* -
- Seventy-one participants with blood sugar levels between 6.5-9% were divided into two groups: one received MC tablets (1,200 mg/day) and the other a placebo for 12 weeks, with their blood sugar control and other health parameters monitored.* -
- Results showed no significant difference in blood sugar levels (HbA1C) or other metrics between the MC and placebo groups, indicating that MC does not effectively lower glucose levels in type
Article Synopsis
- Thai kidney transplant patients can achieve good outcomes with lower doses of mycophenolate, prompting a study on its pharmacokinetics and genetic factors affecting metabolism.
- The study involved 138 stable kidney transplant recipients taking a specific dosage of mycophenolate, measuring MPA concentrations at various times post-dosing, and analyzing genetic variations.
- Findings indicated that despite lower doses, most patients had therapeutic MPA levels, and genetic variations in UGT2B7 were linked to differences in MPA metabolism.
Article Synopsis
- Radiocontrast media (RCM) are drugs used to enhance the visibility of internal organs in X-ray imaging, but can have side effects, including a serious condition known as contrast-induced nephropathy (CIN).
- CIN is characterized by acute renal failure occurring 24-72 hours after RCM exposure, particularly in patients with existing kidney issues or diabetes, and is caused by reduced blood flow and cell damage.
- To prevent CIN, it’s crucial to monitor renal function, use the lowest effective dose of RCM, stay hydrated, and consider medications like N-acetylcysteine for high-risk patients.
Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury.
BMC Complement Altern Med
April 2014
Article Synopsis
- - The study aimed to explore how Phyllanthus emblica (PE) extract could help prevent contrast-induced acute kidney injury (CI-AKI) caused by iodinated contrast agents, which may lead to oxidative stress damage to kidneys.
- - Male rats were divided into groups, receiving either PE extract in different doses or just water, and their kidney function and oxidative stress markers were measured before and after inducing CI-AKI.
- - Results showed that PE extract at higher doses significantly improved kidney function and reduced oxidative damage compared to the control group, indicating its potential protective effects against CI-AKI.
Pharmacological strategies to prevent contrast-induced acute kidney injury.
Biomed Res Int
December 2014
Article Synopsis
- * The mechanisms behind CI-AKI include renal vasoconstriction, increased oxidative stress, and direct damage to kidney tubules.
- * Prevention strategies have been explored, with intravascular volume expansion using isotonic saline or sodium bicarbonate showing the most promise, although some high-risk patients still develop CI-AKI despite these efforts.
Article Synopsis
- - This study explores how recombinant human erythropoietin (rhEPO) could protect kidney cells by promoting regeneration and reducing fibrosis in a mouse model with unilateral ureteric obstruction (UUO).
- - Mice treated with rhEPO showed less tubular atrophy and interstitial fibrosis compared to those receiving a control vehicle, suggesting it can help combat kidney damage.
- - The findings indicate that rhEPO works by inhibiting specific molecular pathways linked to cellular aging and epithelial-to-mesenchymal transition (EMT), presenting it as a potential treatment for chronic kidney disease in humans.
Article Synopsis
- The study investigates the use of urinary neutrophil gelatinase-associated lipocalin (uNGAL) as an early marker for contrast-induced acute kidney injury (CI-AKI) in patients with chronic kidney disease (CKD) undergoing coronary procedures.
- The research involved 130 patients with low kidney function, analyzing urine samples at various time points after contrast administration, and found that uNGAL levels were significantly higher in patients who developed CI-AKI.
- The results indicate that monitoring uNGAL can effectively detect CI-AKI early and predict its severity, potentially improving patient outcomes during cardiac procedures.
Article Synopsis
- Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication after coronary bypass graft (CABG) surgery, often linked to oxidative stress and inflammation, with erythropoietin (EPO) showing promise as a protective agent.
- A study involving 100 patients examined the effects of rHuEPO versus saline, finding significantly lower CSA-AKI rates (14% vs. 38%) and shorter ICU and hospital stays for those receiving EPO.
- The results highlighted that EPO administration led to less elevation in serum creatinine and lower levels of urine NGAL post-surgery, suggesting its effectiveness in reducing kidney injury in patients undergoing CABG.
Article Synopsis
- Contrast-induced nephropathy (CIN) is a major cause of acute kidney injury in hospitals, linked to oxidative stress caused by intravenous radiocontrast agents.
- A study was conducted on male rats to assess the effects of alpha-tocopherol (a form of Vitamin E) on reducing kidney damage from CIN, with various groups receiving different doses prior to CIN induction.
- Results showed that alpha-tocopherol significantly improved renal function, reduced oxidative stress markers, and prevented kidney damage, suggesting its potential as an antioxidant therapy for CIN.