Avoiding Cutaneous Melanoma Requires Proper Sun Protection and a Correspondingly High Level of Education: A Case Control Study.

Background/aim: Cutaneous melanoma ranks 5th among all cancers in terms of estimated new case rates in men and women (6% and 4%, respectively). The most consistent known modifiable risk factor for a cancer of this severity is exposure to ultraviolet rays. In this study, we aimed to compare the sun protection knowledge, habits and behaviors of CM patients with healthy volunteers.

Clinical significances of TTF-1, neuroendocrine (chromogranin, synaptophysin, CD56), and keratin (pancytokeratin, CK7, CK5/6) marker immunostaining in small cell lung cancer.

Purpose: Immunohistochemistry (IHC) markers have established a role in the pathological diagnosis of small cell lung cancer (SCLC) and especially neuroendocrine markers help to differentiate SCLC from other tumors. The study aimed to evaluate the clinical role of different IHC markers in SCLC patients.

Methods: A total of 378 SCLC patients were enrolled in the study and analyzed retrospectively.

Female Patients with Small Cell Lung Cancer Have Better Survival than Males with Extensive but Not Limited Disease.

Introduction: Several previous studies have explored whether sex has prognostic significance in patients with small cell lung cancer (SCLC). In this retrospective study, we aimed to show the clinical significance of sex in SCLC patients.

Methods: A total of 378 SCLC patients were assessed retrospectively.

Prognostic significance of body mass index and serum albumin as the indicators of nutritional status in small cell lung cancer.

Background: Body mass index (BMI) and serum albumin (ALB) level are long-established markers that reflect the nutritional status and eventually the prognosis of cancer patients. The objective of the study was to determine the clinical significance of these factors and specify their roles in outcomes compared with performance status (PS) and weight loss (WL), which are considered the most significant patient-related prognostic factors in small cell lung cancer (SCLC) treated with platinum-etoposide-based chemotherapy.

Methods: A total of 378 patients with SCLC were enrolled in the study and analyzed retrospectively.

A Modified H-index Calculated Using the Duration of Professional Experience and the Author's Significant Contribution to Publications.

Recently, the h-index (HI) has been accepted as a globally valid indicator that measures the professional achievement of scientists. Although it has been criticized in some respects, it is the most frequently used parameter as a criterion that generally measures the number and quality of publications combined. In the evaluation of the scientific publication, apart from these, the duration (years) of professional experience of the scientist and the impact/significance of the author's contribution to publications should also be used; however, HI does not take these into account.

Comorbidity in Small Cell Lung Cancer: Prognostic Impacts of Hypertension/Coronary Artery Disease, Diabetes Mellitus, and Chronic Obstructive Pulmonary Disease.

Comorbidity, the most important components of which are hypertension/coronary artery disease (HTN/CAD), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD), is frequently encountered in small cell lung cancer (SCLC) patients. We aimed to assess the possible impacts of these major comorbidities on the prognoses of SCLC patients. A total of 378 SCLC patients were analyzed retrospectively.

Timing of chemotherapy after diagnosis of small cell lung cancer.

Systemic chemotherapy is the backbone of therapeutic management in small cell lung cancer (SCLC) and delay of treatment may lead to adverse patient outcomes. This study was conducted to determine the time elapsed between pathological diagnosis and initiation of chemotherapy in SCLC patients and to evaluate its clinical significance. A total of 323 pathologically confirmed SCLC patients were enrolled in the study and analyzed retrospectively.

Cutaneous melanoma survival rates of the elderly are not worse than those of the young, yet they have some specific differences.

Introduction: The incidence of cutaneous melanoma among the elderly has increased significantly. Unfavorable survival rates are associated with insufficient patient managements and poor prognostic features in the elderly. We aimed to compare elderly (≥75 years) and younger (<75 years) patients with cutaneous melanoma to determine the differences and the prognostic significance of age.

Primary tumor SUV and ratio of SUV to primary tumor size on pretreatment 18F-FDG-PET/CT scan in small cell lung cancer : Which is superior for the prognosis?

Background: The prognostic impact of tumor SUVmax (t-SUVmax) in small cell lung cancer (SCLC) has been questioned with controversial results, and the significance of the ratio of tumor SUVmax to primary tumor size (SUVmax/t-size) in SCLC has yet to be clarified as well. In this study, a retrospective analysis was carried out to figure out the prognostic and predictive powers of pretreatment primary t‑SUVmax and t‑SUVmax/t-size ratio in patients with SCLC.

Methods: A total of 349 SCLC patients who underwent pretreatment staging with PET/CT scan were enrolled in the study and analyzed retrospectively.

Melanoma publications do not increase as much as the incidence of melanoma in the last two decades.

In recent years, the incidence of melanoma has increased more dramatically than any other malignancy. We compared the number of publications between melanoma and other cancers in the last two decades. We performed a systematic search on PubMed using the search terms "melanoma" and "cancer" to determine the number of publications on melanoma and other cancers.

Online public interest in smoking and lung cancer: A comparative study in Google Trends.

Background: Lung cancer is the leading cause of cancer death globally. There is a causal relationship between smoking and lung cancer; nearly 90% of cases are caused by cigarette smoking.

Aim: To investigate the public interest in the relationship between lung cancer and tobacco smoking through an analysis of searches in Google Trends over the past 16 years.

Diagnosing lung cancer at a younger age and with male dominance: Comparison of Turkish patients with United States patients.

Background: The risk of lung cancer (LC) increases with an older age and is most frequently diagnosed among patients aged 65-74 years with an increasing women ratio over the years in the United States (US).

Aim: This study aimed to demonstrate the age and gender distribution of Turkish LC patients at diagnosis over the past 10 years.

Material And Methods: A total of 5,201 LC patients who had been admitted to the Institute of Oncology, a tertiary referral center, from January 2011 to December 2020 were included in the study.

Neither the presence nor the severity of hyponatremia affected the outcome of the patients with small cell lung cancer.

Background: Hyponatremia is the most common electrolyte disorder in lung cancer, and it particularly occurs in small cell lung cancer (SCLC) patients. The prognostic significance of hyponatremia has been reported in several studies with controversial results.

Aims: We aimed in this study to investigate hyponatremia and evaluate its prognostic value in SCLC patients.

Ulceration vs. Mitosis in Cutaneous Melanoma: Which Is Superior for Predicting Prognosis Across Clinical Stages?

Ulceration and high mitosis are considered among the major unfavorable prognostic factors in the survival of cutaneous melanoma patients. The aim of this study was to investigate the clinical significance of these parameters and to compare them to see which one is superior to predicting prognosis across all clinical stages of melanoma. A total of 1,074 melanomas were analyzed retrospectively.

Breast cancer patients are diagnosed at younger ages in Turkey: a comparative study.

Background: The incidence of breast cancer (BC) has been on the rise over the last decades in the USA, and it is most frequently diagnosed among women aged 65-74 years.

Aims: The aim of this study was to demonstrate the median age of BC at diagnosis and the age-specific incidence ratios of Turkish BC patients over the last 10 years.

Methods: A total of 6009 Turkish BC patients who had been admitted to the Institute of Oncology, a tertiary referral center, from January 2011 to December 2020 were included in the study.

Major Histotypes in Skin Melanoma: Nodular and Acral Lentiginous Melanomas Are Poor Prognostic Factors for Relapse and Survival.

The histological subtype is not considered one of the major prognostic factors in melanoma, yet it is known to have an impact on survival. The aim of this study was to investigate the clinical significance of histological subtypes and the possible impacts of clinicopathological factors on the course of melanoma patients of all stages. A total of 1017 cutaneous melanoma patients were analyzed retrospectively.

Trunk melanomas: no survival differences between lesion sites.

Objectives: The anatomic site of primary melanoma is significantly associated with patient survival, e.g. trunk melanomas have poorer prognosis than limb melanomas.

Successful Treatment of a 92-Year-Old Classic Kaposi's Sarcoma Man With Ultra-Low Dose Oral Etoposide.

Introduction: Because classic Kaposi's sarcoma (CKS) is currently regarded as a low-grade vascular malignancy, it has been usually known as indolent clinical course. The slow-growing neoplasms are usually asymptomatic and rarely systematically progressive. Although CKS is a chronic disease which is rarely life-threatening, systemic therapy may be necessary in some patients with symptomatic skin or visceral involvement.

Different mitotic rates are associated with different prognostic factors, relapses, and survival rates in melanoma.

Background: Mitotic rate is one of the major prognostic factors in melanoma.

Objective: To investigate the significance of mitotic rate and possible impacts of clinicopathological factors on the course of all staged melanoma patients.

Methods: A total number of 970 melanoma patients were analyzed.

Trends in the characteristics of skin melanoma in accordance with time intervals: A single Turkish tertiary referral center experience.

Aim: The incidence of skin melanoma has increased dramatically in recent years. The aim of this study was to analyze the trends in the features of Turkish cutaneous melanoma patients in a 25-year period.

Materials And Methods: A total of 1258 adult melanoma patients who had been managed and followed up at a tertiary referral center between 1993 and 2017 were included in the study.

Efficacy and tolerability of vismodegib treatment in locally advanced and metastatic basal cell carcinoma: Retrospective real-life data.

The study aims to evaluate the vismodegib treatment in local advanced (laBCC) and metastatic (mBCC) basal cell carcinoma. The data of 29 patients were retrospectively reviewed. The clinical and histopathological features of the patients and adverse events of vismodegib were recorded.

Digit melanomas are associated with poor prognostic factors and unfavorable survivals.

Background: The anatomic location of primary melanoma is significantly associated with outcome.

Objective: To evaluate the prognostic factors and survival outcomes associated with melanomas on hand and foot digits.

Methods: The data of 106 patients with digit melanomas were analyzed retrospectively.

Auricular and periauricular melanomas have similar clinicopathologic factors and survival rates.

Background: Auricular melanomas are rare malignancies, and conflicting reports regarding their clinical behaviors have been published so far.

Objective: In this study, we investigated the clinical features of the auricular melanomas and compared them with periauricular skin melanomas.

Methods: Data of 53 primary melanomas arising in auricular (n = 25) and periauricular regions (n = 28) were analyzed retrospectively.