Trehalose protects the endothelium from cadmium-induced dysfunction.

The objective of the present study is to identify the possible regulatory role of trehalose (Tre) against cadmium chloride (CdCl )-induced endothelial cell dysfunction. To screen the dose-dependent effect of both Tre and CdCl , a methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay was performed. Interestingly, MTT assay results have shown that co-incubation of Tre (1 mM) with CdCl significantly decreased the CdCl (5 µM) cytotoxicity.