Crafting tailored, well-defined block copolymers of cyclic esters with an organomagnesium initiator.

An organomagnesium complex containing an imino-phosphanamidinate ligand was found to be a competent catalyst for the ROP of -LA and ε-CL as well as their copolymerization sequential addition of monomers, resulting in the formation of PCL--PLA diblock copolymer. The polymers obtained were characterized by H, C, DOSY NMR, DSC, TGA, POM, and SEM.

Facile access to trifluoromethyl propargyl alcohol by metal-free transfer hydrogenation and cyanation of alkynyl ketones.

We report an efficient synthetic route to the metal-free hydroboration and cyanosilylation of a wide range of alkynyl trifluoromethyl ketones using pinacolborane (4,4,5,5-tetramethyl-1,3,2-dioxaborolane) and trimethylsilyl cyanide under mild reaction conditions at ambient temperature. These highly effective hydroboration and cyanosilylation reactions lead to the corresponding alkynyl trifluoromethyl propargyl alcohols after hydrolysis. In addition, trifluoromethyl (CF) group-based pharmaceutically active enflicoxib analogs were synthesized from propargyl alcohol.

Synthesis of algal-bacterial sludge activated carbon/FeO nanocomposite and its potential in antibiotic ciprofloxacin removal by simultaneous adsorption and heterogeneous Fenton catalytic degradation.

The extensive use of pharmaceuticals has increased their presence in the environment, posing significant ecological and public health concerns. The current study reports the magnetic nanocomposite (M-ABAC) synthesis using the algal-bacterial sludge as the precursor for activated carbon and evaluates its potential in fluoroquinolone antibiotics removal. The activated carbon from algal-bacterial sludge was composited with FeO nanoparticles using the co-precipitation method.

Crafting sustainable solutions: architecting biodegradable copolymers through controlled ring-opening copolymerization.

Polylactic acid (PLA) is a biodegradable and biocompatible polymer with versatile applications in packaging and medicine. It is derived from lactic acid and thus represents an eco-friendly option sourced from renewable raw materials. Despite its advantages, PLA exhibits few drawbacks, such as brittleness and relatively high melting and glass transition temperatures.

Tri-coordinated zinc alkyl complexes with ^/ coordination of imino-phosphanamidinate chalcogenide ligands as precursors for efficient hydroboration of nitriles and esters.

A series of tri-coordinated zinc alkyl complexes with the general molecular formula [-{NHIP(Ph)(E)N-Dipp}ZnEt] [R = Dipp (2,6-diisopropylphenyl), E = S (3a), Se (3b) and R = Bu (-butyl), E = S (4a), Se (4b)] bearing imino-phosphanamidinate chalcogenide ligands were prepared in good yields from the reaction between the protic imino-phosphanamidinate chalcogenide ligand [NHIP(Ph)(E)NH-Dipp] [R = Dipp, E = S (1a), Se (1b) and R = Bu, E = S (2a), Se (2b)] and diethylzinc at room temperature. The molecular structures of all the zinc complexes were established by single-crystal X-ray diffraction analysis. In the solid state, all complexes exhibited a distorted trigonal planar geometry around the zinc ion.

Unprecedented ROP of quinazolinones to polyacylamidines using a cesium catalyst.

Unprecedented ring-opening polymerization of quinazolinones to produce novel polyacylamidines, led by a unique cooperation between a cesium metal center and imino-phosphanamidinate ligand, was developed. Morphological studies revealed the formation of a unique macromolecular assembly producing nanofibers in the absence of a templating agent with excellent control of molecular weights and polydispersity index.

Magnesium-Catalyzed Dye-Embedded Polylactide Nanoparticles for the Effective Killing of Highly Metastatic B16F10 Melanoma Cells.

In the current research, dye-embedded polylactic acid (PLA) conjugate materials were synthesized using one-pot ring-opening polymerization (ROP), i.e., (dtHP) (2-[(2,4,6-trimethylphenyl) imino]-1(2)-acenaphthylenone-reduced-PLA) and (dmHP) (monoiminoacenaphtheneone-reduced-PLA), and then, nanoparticles (NPs) were engineered in the size range of 150 ± 30 nm.

Hydrosilylation of nitriles and tertiary amides using a zinc precursor.

We report a competent and selective hydrosilylation of nitriles and tertiary amides catalyzed by the readily available zinc bis(hexamethyldisilazide) under solvent-free and mild conditions, making it a sustainable and desirable alternative to existing methods. Both protocols afforded high conversion, superior selectivity, and a broad substrate scope, from electron-withdrawing to electron-donating and heterocyclic substitutions.

Role of Bis(phosphinimino)methanides as Universal Ligands in the Coordination Sphere of Metals across the Periodic Table.

The coordination chemistry of bis(phosphinimino)methanide ligands is widespread and accompanies a large number of metal ions in the periodic table ranging from lithium to neptunium. This unique class of ligand systems show copious coordination chemistry with the main-group, transition, rare-earth, and actinide metals and are considered to be among the most attractive ligand systems to researchers. The bis(phosphinimino)methanide metal complexes offer an extensive range of applications in various fields and have been demonstrated as one of the universal ligand systems to stabilize the metal ions in not only their usual but also their unusual oxidation states.

Amidophosphine Boranes as Hydroboration Reagents for Nitriles, Alkynes, and Carboxylic Acids.

We report here the hydroboration of nitriles, alkynes, and carboxylic acids using amidophosphine boranes {(BH)(PPh)-NC(CH)}, {(BH)(PPh)N(CH)CH}, and {(BH)(PPh)N-(BH)CHCHN} as reducing agents. These compounds were synthesized to replace more commonly used borane reagents. Solid amidophosphine boranes, which were synthesized with ease, demonstrated excellent reactivity and functional group tolerance toward a wide variety of nitriles, alkynes, and carboxylic acids, affording the corresponding ammonium salts, alkenes, and alcohols in good yield.

Zinc Catalyzed Hydroboration of Esters and Nitriles with Pinacolborane.

We developed a bench-stable iminopyridine-ligated zinc complex for the effective catalytic hydroboration of esters and nitriles under solvent-free conditions. Various esters and nitriles bearing different functionalities were selectively reduced to form corresponding alcohols and amines in good yields. Detailed Hammett plots are provided to explain the electronic effects on the phenyl ring.

Highly efficient and well-controlled ROP and copolymerization of cyclic esters using a cesium complex.

A cesium imino-phosphanamidinate, [{NHIP(Ph)NDipp}Cs], enabling efficient ring-opening (co)polymerization of -LA and ε-CL is disclosed. Owing to the highly controlled polymerization, precise di-block copolymers (PLA--PCL) with different block lengths can be produced by a simple one-pot reaction. NMR, GPC, DSC and microscopic analyses confirm the production of di-block copolymers with crystalline properties.

Correction: NHC-Zn alkyl catalyzed cross-dehydrocoupling of amines and silanes.

Correction for 'NHC-Zn alkyl catalyzed cross-dehydrocoupling of amines and silanes' by Adimulam Harinath , , 2023, https://doi.org/10.1039/d3ob00453h.

NHC-Zn alkyl catalyzed cross-dehydrocoupling of amines and silanes.

An -heterocyclic carbene-zinc alkyl complex [ImZn(CHCH)] (Im = imidazol-2-ylidene and Dipp = 2,6-diisopropylphenyl) acts as a catalyst in the cross-dehydrogenative coupling (CDC) of a wide range of primary and secondary amines and hydrosilanes to yield a substantial quantity of the corresponding aminosilanes with good chemoselectivity at room temperature. A broad substrate scope was observed during the zinc-catalyzed CDC reaction. Two zinc complexes, [{ImZn(-NHPh)(NHPh)}] (Mes = mesityl) (3) and [{ImZn(CHCH)(-H)}] (4), were isolated and structurally characterized as intermediates through controlled reactions to ascertain the CDC mechanism.

Design and synthesis of photostable triphenylamine based neutral AIE nano luminogens: specific and long-term tracking of mitochondria in cells.

With the increasing dependence on fluorescence bioimaging, luminogens with aggregation-induced emission (AIE) properties have gained significant attention due to their excellent photostabilization, minimal photobleaching, high reliability, and superior biocompatibility. Since mitochondria are crucial subcellular organelles in eukaryotic cells with important biological functions, organelle-specific AIE emitters with distinct functions have been highly sought after, but with limited success using simple synthetic methods. Here, we describe a strategy for synthesizing two triphenylamine (TPA) based acrylonitriles, tethered to different donor groups, TPA and phenothiazine (PTZ), respectively, with superior AIE properties using Suzuki coupling.

N^N N^E (E = S or Se) coordination behavior of imino-phosphanamidinate chalcogenide ligands towards aluminum alkyls: efficient hydroboration catalysis of nitriles, alkynes, and alkenes.

The synthesis, characterization, and catalytic application of six aluminum alkyl complexes supported by various imino-phosphanamidinate chalcogenide ligands are described. Six different unsymmetrical imino-phosphanamidinate chalcogenide ligands [NHIP(Ph)(E)NH-Dipp] [R = 2,6-diisopropylphenyl (Dipp), E = S (2a-H), Se (2b-H); R = mesityl (Mes), E = S (3a-H), Se (3b-H); R = -butyl (Bu), E = S (4a-H), Se (4b-H)] were prepared by the oxidation of respective imino-phosphanamide ligands (1a, 1b and 1c) with elemental chalcogen atoms (S and Se). The aluminum complexes with imino-phosphanamidinate chalcogenide ligands with the general formulae [κ-{NHIP(Ph)(E)N-Dipp}AlMe] [R = Dipp, E = S (5a), Se (5b); R = Mes, E = S (6a), Se (6b)] or [κ-{NHIP(Ph)(E)N-Dipp}AlMe] [R = Bu, E = S (7a), Se (7b)] were synthesized in good yields from the reaction of the suitable protic ligands (2a,b-H-4a,b-H) and trimethylaluminum in a 1 : 1 molar ratio in toluene at room temperature.

Clinical diversities of patient eye care in para-COVID-19 era in Western Odisha.

Background: Coronavirus disease (COVID-19) pandemic had an unprecedented effect on eye care services. The present study was conducted to assess the varied eye diseases and care around COVID-19 pandemic.

Methods: This retrospective study was conducted at BBMCH, Balangir, Ophthalmology Department, Western Odisha, from September 2019 to May 2021 in three phases (i.

Metal/Non-Metal Catalyzed Activation of Organic Nitriles.

Nitrile activation is a prominent topic in recent developments in chemistry, especially in organic, inorganic, biological chemistry, as well as in the natural synthesis of products and in the pharmaceutical industry. The activation of nitriles using both metal and non-metal precursors has attracted several researchers, who are exploring newer ways to synthesize novel compounds. Nitrile activation can be achieved by combining various catalytic double hydroelementation reactions, such as hydrosilylation, hydroboration, and hydrogenation of organonitriles using silanes, pinacolborane, and other sources of hydrogen.

Aluminium alkyl complexes supported by imino-phosphanamide ligand as precursors for catalytic guanylation reactions of carbodiimides.

Herein, we report the synthesis, characterisation, and application of three aluminium alkyl complexes, [κ-{NHIP(Ph)NDipp}AlMe] (R = Dipp (2a), Mes (2b); Bu (2c), Dipp = 2,6-diisopropylphenyl, Mes = mesityl, and Bu = -butyl), supported by unsymmetrical imino-phosphanamide [NHIP(Ph)NDipp] [R = Dipp (1a), Mes (1b), Bu (1c)] ligands as molecular precursors for the catalytic synthesis of guanidines using carbodiimides and primary amines. All the imino-phosphanamide ligands 1a, 1b and 1c were prepared in good yield from the corresponding N-heterocyclic imine (NHI) with phenylchloro-2,6-diisopropylphenylphosphanamine, PhP(Cl)NHDipp. The aluminium alkyl complexes 2a, 2b and 2c were obtained in good yield upon completion of the reaction between trimethyl aluminium and the protic ligands 1a, 1b and 1c in a 1 : 1 molar ratio in toluene the elimination of methane, respectively.

A highly efficient Ti-catalyst for the deoxygenative reduction of esters under ambient conditions: experimental and mechanistic insights from DFT studies.

In this paper, we report the synthesis of dianionic amidophosphineborane-supported titanium chloride [{PhP(BH)N}CHTiCl] (1) and Ti alkyl complex [{PhP(BH)N}CHTi(CHSiMe)] (2) using a salt metathesis reaction. Ti complex 1 was obtained by the reaction of the bis-borane ligand [{PhP(BH)NH}CH] and TiCl in toluene followed by the addition of 2 equivalents of [LiN(SiMe)] at ambient temperature. Ti bis-alkyl complex 2 was isolated from the reaction of complex 1 with 2.

Aluminium complexes: next-generation catalysts for selective hydroboration.

Organoboranes obtained from hydroboration reactions are one of the important classes of compounds that could be used to provide valuable synthons for follow-up transformations such as various functional group incorporation or C-C bond forming reactions. For decades, various transition metals were utilised as catalysts in such transformations. Recently Earth-abundant and less toxic main group metals have revived their importance in hydroboration chemistry, among which the suitable candidates are aluminium complexes as catalysts.

Hydroboration and reductive amination of ketones and aldehydes with HBpin by a bench stable Pd(II)-catalyst.

A palladium(II) complex [(κ-{1,2-CH(NCH-CHO)}Pd] (1) supported by a dianionic salen ligand [1,2-CH(NCH-CHO)] (L) was synthesised and used as a molecular pre-catalyst in the hydroboration of aldehydes and ketones. The molecular structure of Pd(II) complex 1 was established by single-crystal X-ray diffraction analysis. Complex 1 was tested as a competent pre-catalyst in the hydroboration of aldehydes and ketones with pinacolborane (HBpin) to produce corresponding boronate esters in excellent yields at ambient temperature under solvent-free conditions.

Catalytic Hydroboration and Reductive Amination of Carbonyl Compounds by HBpin using a Zinc Promoter.

The chemoselective hydroboration of aldehydes and ketones, catalyzed by Zinc(II) complexes [κ -(PyCH=NR)ZnX ] [R=CPh , X=Cl (1) and R=Dipp (2,6-diisoropylphenyl) and X=I (2)], in the presence of pinacolborane (HBpin) at ambient temperature and under solvent-free conditions, which produced the corresponding boronate esters in high yield, is reported. Zinc metal complexes 1 and 2 were derived in 80-90% yield from the reaction of iminopyridine [PyCH=NR] with anhydrous zinc dichloride in dichloromethane at room temperature. The solid-state structures of both zinc complexes were confirmed using X-ray crystallography.