Publications by authors named "Taru Lehtonen"
Article Synopsis
- The study examined early-onset colorectal cancer (EO-RC) in patients under 50, revealing an increased incidence and aimed to assess characteristics, mortality, and recurrence rates of this group.
- During the analysis of 2557 rectal cancer patients from 2007-2021, 147 were aged 18-49; survival rates were fairly high across varying stages of cancer, with no significant annual trends observed in EO-RC cases.
- Overall, 91.9% of stage I patients survived five years, and while some predisposing factors were noted, the disease progression and survival outcomes for EO-RC patients were similar to those in the general rectal cancer population.
Background: Lynch syndrome (LS) is one of the most common hereditary cancer syndromes worldwide. Dominantly inherited mutation in one of four DNA mismatch repair genes combined with somatic events leads to mismatch repair deficiency and microsatellite instability (MSI) in tumours. Due to a high lifetime risk of cancer, regular surveillance plays a key role in cancer prevention; yet the observation of frequent interval cancers points to insufficient cancer prevention by colonoscopy-based methods alone.
View Article and Find Full Text PDFAim: This study aimed to examine the diagnostic accuracy and prognostic value of magnetic resonance imaging (MRI) detected lymph nodes in rectal cancer.
Method: We evaluated 806 rectal cancer patients consecutively operated on between 2015 and 2018 at Helsinki University Hospital. In total, 485 patients met the inclusion criteria of presenting with stage I-III disease and were intended for curative treatment at the time of diagnosis.
Aim: This study aimed to examine the prognostic value of extramural venous invasion observed in preoperative MRI on survival and recurrences.
Method: In total, 778 rectal cancer patients were evaluated in multidisciplinary meetings in Helsinki University Hospital during the years 2016-2018. 635 patients met the inclusion criteria of stage I-III disease and were intended for curative treatment at the time of diagnosis.
Article Synopsis
- A study aimed to evaluate the effectiveness of mechanical and oral antibiotic bowel preparation (MOABP) versus no bowel preparation (NBP) for patients undergoing colon resection surgeries, as previous reports indicated a reduction in surgical site infections (SSIs) with MOABP.
- The research was conducted as a multicenter, single-blinded trial in Finland, where patients were randomly assigned to either MOABP or NBP, ensuring that various medical personnel were blinded to the treatment allocation.
- The main focus was to determine the incidence of SSIs within 30 days post-surgery in patients who underwent elective colon resection with an anastomosis, and the trial has since been registered and closed to new participants.
BACKGROUND Kidney transplantation is reported to save costs compared to maintenance dialysis. We analyzed the current actual costs of kidney transplantation compared to dialysis, and analyzed risk factors for higher costs after transplantation. MATERIAL AND METHODS Altogether, 338 kidney transplant recipients between 2009 and 2014 were included in this study.
View Article and Find Full Text PDFPurpose: To study mortality in severe acute pancreatitis (SAP) and to identify risk factors for mortality.
Materials And Methods: A retrospective 17-years' cohort study of 435 consecutive adult patients with SAP treated at intensive care unit of a university hospital.
Results: Overall, 357 (82.