Publications by authors named "Taro Kogami"
REV7 is a multifunctional protein essential for promoting cellular tolerance to DNA damage. REV7 expression is associated with disease progression and prognosis in several human malignant tumors. This study aimed to evaluate the clinical and biological significance of REV7 in gastric adenocarcinoma (GAD).
View Article and Find Full Text PDFREV7 is a multifunctional protein implicated in various biological processes, including DNA damage response. REV7 expression in human cancer cells affects their sensitivity to DNA-damaging agents. In the present study, we investigated the significance of REV7 in pancreatic ductal adenocarcinoma (PDAC).
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- A 76-year-old man with a month-long history of epigastric pain was diagnosed with pancreatic neuroendocrine carcinoma (PanNEC) after imaging revealed a mass in the pancreatic head and liver nodules, along with signs of jaundice and hepatic dysfunction.
- Initial treatments included platinum-based chemotherapy and streptozotocin, but the patient showed progressive disease, leading to the addition of pembrolizumab, specifically targeting his high microsatellite instability (MSI-high) status.
- Despite a temporary improvement in his condition, the patient ultimately experienced disease progression and passed away 1 year and 7 months after diagnosis, highlighting the need to routinely check MSI status in PanNEC cases for better treatment responses.
We herein report a rare case of cartilage-hair hypoplasia (CHH) complicated with liver cirrhosis. A 20-year-old Japanese man with CHH was found incidentally to have liver cirrhosis and an esophageal varix. This patient had been treated for infections due to immunodeficiency since early childhood.
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