Publications by authors named "Taro Hiromi"
Article Synopsis
- The COVID-19 pandemic led to increased reliance on mechanical ventilation (MV) and higher mortality rates, especially among severe cases needing ECMO.
- Researchers analyzed data from 102 COVID-19 patients and found that specific biomarkers (SpO2/FiO2 ratio, IL-6 levels, and SARS-CoV-2 RNA) can predict poor outcomes after MV use.
- Combining these biomarkers generates a high predictive accuracy for mortality, indicating that patients with poor SpO2/FiO2 and elevated IL-6 and SARS-CoV-2 RNA levels face a significantly increased risk of fatal events.
Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation.
Arterioscler Thromb Vasc Biol
June 2020
Objective: Excessive prostaglandin E production is a hallmark of abdominal aortic aneurysm (AAA). Enhanced expression of prostaglandin E receptor EP4 (prostaglandin E receptor 4) in vascular smooth muscle cells (VSMCs) has been demonstrated in human AAAs. Although moderate expression of EP4 contributes to vascular homeostasis, the roles of excessive EP4 in vascular pathology remain uncertain.
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- Abdominal aortic aneurysm (AAA) is a serious condition that becomes more common with age, but there are currently no effective medications to slow its progression.
- Research indicates that blocking the prostaglandin E receptor EP4, using a drug called CJ-42794, can help reduce AAA size and related issues in mouse models.
- CJ-42794 treatment not only decreased aortic diameter and damage to elastic fibers but also reduced harmful protein levels associated with AAA, suggesting it could be a promising new approach for treating this disease.
Cases: Septic cardiomyopathy is defined as a reversible left ventricular systolic dysfunction. Patients with severe septic cardiomyopathy have a high mortality rate, even if they receive conventional therapy. For those patients, previous reports showed intra-aortic balloon pump (IABP) efficacy.
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