Efficacy of letrozole for advanced breast cancer in postmenopausal patients.

Objective: To evaluate the clinical benefit and tolerability of letrozole after tamoxifen failure in locally advanced, recurrent or metastatic breast cancer in postmenopausal patients.

Design: A phase II non-randomized trial.

Place And Duration Of Study: Oncology Department, Combined Military Hospital, Rawalpindi, from March 1999 to February 2001 over a period of 2 years.

Toxicity profile and objective response of paclitaxel in metastatic breast cancer.

Objective: To evaluate the efficacy and toxicity of 1-hour weekly Paclitaxel in metastatic breast cancer along with evaluation of overall survival.

Design: A phase II interventional trial.

Place And Duration Of Study: Oncology Department, Combined Military Hospital, Rawalpindi, between August 2001 to July 2003.

Management of oromandibular cancers.

Objective: To emphasize the role and importance of multidisciplinary approach in the management of oral cavity cancers involving the mandible.

Design: Descriptive study.

Place And Duration Of Study: The Departments of Plastic and Reconstructive Surgery, ENT / Head and Neck Surgery and Radiation Oncology, Combined Military Hospital, Rawalpindi.