Publications by authors named "Tariq Alpakistany"
Article Synopsis
- Superbugs, which are antibiotic-resistant bacteria, are causing fatal infections globally, exacerbated by factors like migration, urbanization, and poor sanitation.
- The CRISPR-Cas system, particularly type II, is promising for editing the genomes of drug-resistant bacteria, but requires further advancements to reduce toxicity and improve effectiveness.
- This review examines CRISPR limitations and highlights new base-editing techniques, such as adenine and cytidine base editors, which can directly change specific DNA bases to help eliminate drug-resistant microbes.
Background: There is a sudden rise in infectious diseases, with special concern to the most recent SARS-CoV 2 outbreak. A retrospective study was conducted to study the effect of this outbreak on neonatal sepsis as a global issue that poses a challenge for pediatric management and to identify its risk factors, microbial profile, and mortality rate at King Faisal Medical Complex, Taif, KSA, a COVID-19-tertiary care segregation hospital.
Methods: This research included 111 neonates with a culture-proven diagnosis of neonatal sepsis (4 and 62 cases during 2019 and 2020, respectively).