Molecular dynamics-based computational investigations on the influence of tumor suppressor p53 binding protein against other proteins/peptides.

The tumor-suppressing p-53 binding protein is a crucial protein that is involved in the prevention of cancer via its regulatory effect on a number of cellular processes. Recent evidence indicates that it interacts with a number of other proteins involved in cancer in ways that are not fully understood. An understanding of such interactions could provide insights into novel ways p53 further exerts its tumour prevention role via its interactions with diverse proteins.

A Modification on Hoffman's Pocket Technique With Scleral Fixation of Intraocular Lens (IOL), Case Series of Unique Scenarios.

The purpose of this study is to present our experience with Hoffman's SFIOL using double-armed Gore-Tex sutures (polytetrafluoroethylene) instead of 9.0 polypropylene suture method in four cases. In this case series article, we present our experience with Hoffman's SFIOL using double-armed Gore-Tex sutures (polytetrafluoroethylene) instead of 9.

Bilateral Retinal Infiltration and Ischemia as the First Presenting Sign of Chronic Myeloid Leukemia: A Case Report with Multimodal Imaging.

Chronic myeloid leukemia (CML) is a malignant proliferative disorder involving the bone marrow and lymphatic system. Retinal involvement is a rare form of presentation in patients with CML. We report a case of a 49-year-old woman who presented with an acute bilateral visual disturbance.

Efficacy of Biomarkers in Predicting Anastomotic Leakage After Gastrointestinal Resection: A Systematic Review and Meta-Analysis.

Our systematic review and meta-analysis were designed to evaluate the published literature from 2016 to 2019 on which the role of biomarkers in predicting the anastomotic leakage (AL) in gastroesophageal cancer surgery was investigated. This extensive literature search was conducted on the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Excerpta Medica dataBASE (EMBASE) were used to gather the relevant information.

Knowledge and attitudes of gout patients and their perspectives about diagnosis and management: A cross-sectional study in Saudi Arabia.

Background: Gout is a chronic noncommunicable disease that might lead to multiple systemic complications if it is left untreated. The knowledge, attitudes, and perceptives among patients toward the diagnosis and management of gout are important indicators in determining the prognosis and predicting sequelae of the disease. This cross-sectional survey aimed to assess the knowledge, attitudes, and perspectives of patients diagnosed with gout toward the disease diagnosis and treatment.

Assessment of health promotion behavior and associated factors among the northern Saudi adolescent population: a cross-sectional study.

Background And Aim: Health promotions among the adolescent population have a significant role in achieving the 2030 sustainable development goals of the World Health Organization. The COVID-19 pandemic has led to several devastating impacts on the health, economic, social, and healthcare systems, and adolescents' health promotions are no exception. We assessed health promotion behaviors and associated factors among the adolescent population of northern Saudi Arabia (KSA).

Reported effects of the COVID-19 pandemic on the psychological status of emergency healthcare workers: A scoping review.

Background: While literature on psychological consequences among frontline healthcare workers (HCWs) flourishes, understanding the psychological burden on this group is particularly crucial, as their exposure to COVID-19 makes them especially at high risk. We explored what is known about psychological effects of the COVID-19 pandemic on emergency HCWs.

Methods: We used a scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.

Do various personal hygiene habits protect us against influenza-like illness?

Background: Several studies have reported an association between improvements in hand hygiene and the reductions in rates of intestinal parasitic diseases. However, only a some have addressed its link to the frequency of influenza-like illness. The current study aimed to find the correlation between personal hygiene habits and the frequency of influenza-like illness.

Ear diseases and factors associated with ear infections among the elderly attending hospital in Arar city, Northern Saudi Arabia.

Background: Changes in the anatomical structures and function of the ear can result in ear diseases, and may affect all age groups including the elderly as a result of aging.

Objective: To identify the frequency and types of ear diseases among the elderly attending Abdullah bin Abdul-Aziz bin Musa'ed Al Saud hospital, Arar city, in the Northern Province of KSA, and factors associated with ear infections among them.

Methods: This cross-sectional hospital based study conducted from December 2016 through May 2017 included 138 elderly participants.

Prevalence, risk factors and character of abdominal hernia in Arar City, Northern Saudi Arabia in 2017.

Background: Abdominal wall hernias are a very common surgical condition affecting all ages and both sexes. The main risk factors of hernias include pregnancy, weight lifting, constipation, and weight gain.

Objective: The aim of this study was to determine the prevalence and risk factors of abdominal hernias, their causes, treatment and complications among both sexes of the Arar population (Saudi Arabia).