Cholesterol dependent cytolysins and the brain: Revealing a potential therapeutic avenue for bacterial meningitis.

Bacterial meningitis is a catastrophic nervous system disorder with high mortality and wide range of morbidities. Some of the meningitis-causing bacteria occupy cholesterol dependent cytolysins (CDCs) to increase their pathogenicity and arrange immune-evasion strategy. Studies have observed that the relationship between CDCs and pathogenicity in these meningitides is complex and involves interactions between CDC, blood-brain barrier (BBB), glial cells and neurons.

Early detection of a possible multidrug-resistant outbreak in the local hospital setting by using random amplified polymorphism DNA-polymerase chain reaction (RAPD-PCR), oxacillinase gene profiles, and antibiograms.

Background And Objectives: Detecting the source of a potential outbreak of multidrug resistant (MDR) is necessary to be investigated. This study aimed to detect the possibility of outbreak in a hospital setting using a combination of random amplified polymorphism DNA-polymerase chain reaction (RAPD-PCR), antibiograms, and the presence of oxacillinase genes.

Materials And Methods: The antibiogram of 31 clinical isolates and six environmental isolates of were determined by Vitek® 2 Compact.

A large cluster of human infections of in Bali, Indonesia.

A cluster of 18 inpatients and 21 outpatients with a major complaint of meningitis and a history of sharing traditional delicacies of raw pork and pig blood in a village festival led to the suspicion of meningitis in Sibang Kaja Village, Badung, Bali, Indonesia. We conducted an investigation and case finding to prevent human fatalities. Demography and laboratory examinations of the inpatients were recorded.

Identification and Distribution of Pathogens in a Major Tertiary Hospital of Indonesia.

The nosocomial persistence of multiple drug resistance organisms constitutes a global threat. Healthcare-setting acquired infections are subject to substantial selection pressure and are frequently associated with drug resistance. As part of the microbiological surveillance of the Sanglah tertiary referral hospital in the island province of Bali, the distribution of bacterial pathogen and their relative susceptibilities were recorded over a 30 months period.

Streptococcus suis-Associated Meningitis, Bali, Indonesia, 2014-2017.

Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected during 2014-2017.

Misidentification of as a Zoonotic Agent.

Background: is an emerging zoonotic pathogen. This bacterium commonly causes meningitis in human and is often associated with hearing and vestibular dysfunction. tends to be misidentified, leading to under-diagnosis.