Effect of Sofosbuvir Administration and Its Withdrawal on the Submandibular Salivary Gland of Adult Male Albino Rats: A Histological and Ultra-Structural Study.

Background: Sofosbuvir (SOF) was approved in 2013 as a part of first-line treatment for hepatitis C virus (HCV); it has activity against all genotypes with extrahepatic adverse effects have recently arisen.

Aim: Investigating sofosbuvir-induced alterations in the rat submandibular salivary gland (SMSG).

Methods: A group of 80 adult albino rats weighing about ± 150 gm were used in the experiment.