NAAA-regulated lipid signaling governs the transition from acute to chronic pain.

Chronic pain affects 1.5 billion people worldwide but remains woefully undertreated. Understanding the molecular events leading to its emergence is necessary to discover disease-modifying therapies.

Persistent Exposure to Δ-Tetrahydrocannabinol during Adolescence Does Not Affect Nociceptive Responding in Adult Mice.

Evidence suggests that Δ-tetrahydrocannabinol (Δ-THC), the intoxicating component of cannabis, causes enduring changes in the structure and function of adolescent brain circuits implicated in nociceptive responding. However, whether such changes might persistently disrupt nociceptive behaviors remains unknown. In the present study, we subjected C57BL6/J mice of both sexes to once-daily injections of Δ-THC (5 mg-kg, i.

Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain.

The use of products derived from hemp - i.e., cannabis varieties with low Δ-tetrahydrocannabinol (Δ-THC) content - as self-medication for pain and other health conditions is gaining in popularity but preclinical and clinical evidence for their effectiveness remains very limited.