Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy.

Background: Capecitabine is an oral fluoropyrimidine that is used to treat various malignancies. Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine that can limit the use of this agent in some patients. Some investigators have observed that pyridoxine (vitamin B6) can ameliorate HFS that is caused by capecitabine.

Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review.

Introduction: Paraneoplastic neurological syndromes (PNS) are uncommon and imperfectly understood and, therefore, are frequently underdiagnosed.

Methods: We review the current literature on the clinical presentation, diagnosis, pathophysiology and treatment of PNS.

Results: PNS are a heterogeneous group of neurologic disorders caused by an immune response to an underlying malignancy.