Publications by authors named "Tarek Firzli"
Article Synopsis
- The study investigates the impact of Temperature-Related Illness (TRI) on inpatients with Atrial Fibrillation (AF), focusing on mortality rates and the costs associated with their care.
- Using data from the Nationwide Inpatient Sample (2005-2015), researchers found that patients with both AF and TRI experiences longer hospital stays, higher healthcare costs, and greater chances of requiring invasive mechanical ventilation.
- While the prevalence of TRI among AF patients is low, it has doubled over the decade, with cold-related illnesses particularly associated with significantly higher mortality rates.
Background: Sepsis is marked by elevated histamine, which is a vasodilator that increases vascular permeability. Although human studies are lacking, murine models of sepsis have indicated potential protective effects of histamine 2 receptor antagonist administration (H2RAs).
Objective: To assess any association between H2RA use in sepsis-3 patients admitted to the ICU and mortality, mechanical ventilation, length of stay, and markers of renal, liver, and lung dysfunction.
Article Synopsis
- Vasopressors, particularly norepinephrine (NE), are crucial in treating sepsis, especially when fluid resuscitation isn't effective, and earlier use of these medications may lead to better patient outcomes.* -
- A study analyzed data from 2,079 ICU patients meeting sepsis-3 criteria and found that early NE administration (within 6 hours of admission) was linked to lower mortality rates but higher chances of requiring mechanical ventilation, with no significant impact on overall hospital stay length.* -
- The research concludes that initiating NE early in sepsis cases can reduce mortality and ICU stay duration, highlighting the importance of managing fluid volumes effectively before NE administration.*
Missing data is a significant issue in metabolomics that is often neglected when conducting data preprocessing, particularly when it comes to imputation. This can have serious implications for downstream statistical analyses and lead to misleading or uninterpretable inferences. In this study, we aim to identify the primary types of missingness that affect untargeted metabolomics data and compare strategies for imputation using two real-world comprehensive two-dimensional gas chromatography (GC × GC) data sets.
View Article and Find Full Text PDFAcute respiratory distress syndrome (ARDS) is a severe complication of coronavirus disease 2019 (COVID-19) infection marked by increased fluid diffusely in alveolar spaces. The management of ARDS can be complicated by mechanical hyperinflation, and thus a mainstay of treatment has included low tidal volume mechanical ventilation. This, however, can lead to ventilation-associated hypercapnia, which may result in respiratory acidosis.
View Article and Find Full Text PDFSARS-COV-2 (COVID-19) is a novel virus that has caused over 28 million cases worldwide and over 900,000 deaths since early 2020, rightfully being classified as a pandemic. COVID-19 is diagnosed via polymerase chain reaction testing which looks at cycle threshold (CT) values of two genes, N2 and E. This study examined CT values of COVID-positive patients at the VA hospital in Reno as well as other lab values and comorbidities to determine if any could aid clinicians in predicting the need for hospitalization and higher levels of care.
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