Publications by authors named "Tarek Elgendy"
Background: We evaluated the outcome of vertical rectus abdominus myocutaneous flap (VRAM) allotransplantation in a mini-pig model, using a combined co-stimulation blockade (Co-SB) and mechanistic target of rapamycin inhibition (mTORi)-based regimen, with or without preceding calcineurin inhibition (CNI).
Materials And Methods: VRAM allotransplants were performed between SLA-mismatched MGH miniature swine. Group A (n = 2) was treated continuously with the mTOR inhibitor rapamycin from day -1 in combination with the Co-SB agent cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig) from post-operative day (POD) 0.
Background: Vascularized composite tissue allotransplantation (VCA) opens new possibilities for reconstruction of complex tissue defects, including upper extremity and facial transplantation. The main challenges in VCA transplantation are the side effects of long-term immunosuppression and chronic graft rejection. Translational preclinical animal models are crucial for VCA research to improve clinical outcomes and to study underlying immunologic mechanisms.
View Article and Find Full Text PDFBackground: Spinal resections can lead to defects requiring soft-tissue reconstruction. The purpose of this study was to review the authors' institutional experience with reconstruction of spinal defects and identify risk factors predictive of wound complications, focusing on timing of reconstruction with ablative surgery.
Methods: The authors retrospectively reviewed patients who underwent spinal resection and required soft-tissue reconstruction from 2002 to 2014.
Article Synopsis
- Orbital floor fractures in children are rare, and this study analyzed the presentation, treatment, and results for 72 cases over 21 years.
- About half of the fractures were minimally displaced, while a smaller proportion were more severe types like blowout and trapdoor fractures; many patients had visual issues upon initial examination.
- Surgical intervention was necessary for some patients, mainly due to fracture size and muscle entrapment, but it did not enhance visual outcomes even though it significantly reduced the risk of enophthalmos in the long term.