Publications by authors named "Tarasova S"

Background: This study is an attempt to identify psychological markers for pupils' maladaptive states. Agggression is seen as behavior while aggressiveness is seen as the state of being ready for such behavior. Anxiety is considered a stable personality trait.

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Currently in Russia, there is a rather complicated situation with the distribution of expensive disease modifying drugs (DMD) purchased by the state for treatment of patients with multiple sclerosis. In this regard, it is necessary to carry out a serious organizational work in the direction of assessment of equivalence of biosimilars and original drugs concerning, first of all, efficacy and safety. Also, there is a problem of the replacement of one biosimilar by another in connection with organizational problems of shipping DMD to country regions.

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The combined effect of acute gamma-irradiation at doses of 0, 50, 100, 150 and 200 Gy and nitrates in concentrations of 0.04 g/dm3 (that corresponds to maximum permissible concentrations for fishery waters), 0.1, 0.

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Efficacy of antidepressants fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache has been studied. Amitriptyline had the highest effect in dosage 50 mg daily but was not well tolerated by patients that resulted in that only 50% of them finished the study. Fluvoxamine had high efficacy and good tolerability in the treatment of chronic daily headache and medication overuse headache.

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Physical loading raises the sympathetic nervous activity which results in increased minute volume, constriction of peripheral vessels, and elevated blood pressure. These reactions are an outcome of two mechanisms: 1) the central command from cerebral structures that trigger voluntary movements to activate the vasomotor center and 2) the reflexes initiated by mechanic and metabolic changes in a working muscle. The second mechanism of the sympathetic system activation was termed ergoreflex.

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Efficacy and safety of the following antidepressants: amitryptiline (tricyclic antidepressant), escitalopram (selective inhibitor of serotonin reuptake), milnacipran (selective inhibitor of serotonin and noradrenalin reuptake) and maprotiline (selective inhibitor of noradrenalin reuptake) have been compared during the treatment of 120 patients with chronic daily headache. A positive effect was found for all drugs, in particular in the presence of depressive and anxiety symptoms. Most effective proved to be milnacipran and amitryptiline.

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Efficacy of 4 medications--topiramate, valproate, gabapentine and carbamazepine--was studied in 180 patients: 84 with chronic migraine, 63 with chronic headache of tension and 33 with a combination of the above types of headache. Mean age of the patients was 40,4+/-11,7 (from 19 to 65 years), most patients were female (n=152). The treatment was conducted during 12 weeks with assessment of efficacy every 2 weeks and 4 weeks after the end of the treatment.

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This study investigate the mutual fine-tuning of ongoing EEG rhythmic features with RGB values controlling color shades of computer screen during neuro-feedback training. Fifteen participants had not been informed about the existence of neurofeedback loop (NF), but were guided only to look at the computer screen. It was found that during such unconscious NF training, a variety of color shades on the screen gradually changed from rather various types to the main one within the framework of color palette specified for each individual.

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Minimal brain dysfunctions in children with various perinatal complications are accompanied by metabolic imbalance manifested by decreased total protein content, the tendency to reduced triglycerides, increased cholesterol concentrations in the oral fluid, the trend to hypoproteinaemia, hypoglycaemia, hypotriglyceridaemia. The most significant changes in the redox systems alpha-ketoglutarate-glutamate, oxaloacetate-malate, pyruvate-lactate, dioxyacetone phosphate-alpha-glycerophosphate in biological fluids were revealed in cases of antenatal alcoholisation. A certain correlation was found between anemia in pregnant women and hypothyroidal background in children.

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Twelve synthetic peptides corresponding to 9 immunodominant regions of structural proteins of human retroviruses HTLV-I, HIV-1, and HIV-2 were studied in enzyme-linked immunosorbent assay for cross reactivity with heterotypical for each peptide anti-retroviral antibodies. The search of amino acid homologies was carried using the special computer program followed by the correspondence analysis of the discovered homologies and immunodominant fragments. It was found that peptides 100-130 p19 gag HTLV-I, 376-392 gp21 env HTLV-I, 381-400 gp21 env HTLV-I, 306-328 gp120 env HIV-1, 495-516 gp120 env HIV-1, 584-612 gp41 env HIV-1, and 581-603 gp36 env HIV-2 have type-specific reactivity and also cross react with 3-54% human sera containing antibodies against heterotypical retroviruses.

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The mechanism of antiviral activity of the CD4-derived peptide 75-99 was compared with that of sulfated polysaccharides. A set of peptides representing all the high positive charge density regions of gp120 and gp41 was used to determine whether electrostatic interactions occur between these negatively charged agents and positively charged HIV envelope fragments. Synthetic peptide AZ2, amino acids 75-99 from V1 CD4, KIEDSDTYIC(Acm)-EVEDQKEEVQLLVFG, and dextran sulfate 500,000 (DS 500) were used as inhibitory agents of antibody binding in ELISA using: (1) anti-peptide rabbit antibodies; (2) sera from HIV infected persons.

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It was shown possible to use feeding of hydrogen peroxide as a method for investigating the impact of dissolved oxygen concentrations on growth and development of microorganisms. The influence of pO2 on the respiration intensity was studied in penicillin- and erythromycin-producing cultures and it was found that dependence of the respiration intensity on pO2 had the form of a curve with saturation, at pO2 equal to zero the value of the culture respiration intensity being different from zero. A mathematical model accounting for the presence in the fermentation broth of microbial agglomerates with the average size depending on the agitation conditions is proposed for describing the relationships.

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The data on changes in the partial pressure of carbon dioxide (pCO2) dissolved in the fermentation broth in the course of biosynthesis of tetracycline made in a 63 m3 fermenter are presented. It is shown that pCO2 equal approximately to 2 cPa was optimal for tetracycline biosynthesis. The total carbonate concentration and pCO2 were estimated simultaneously in the process of tetracycline fermentation.

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Theoretical analysis of the relationship between the rates of the biomass growth mu and biosynthesis of the metabolites q was performed, when the both kinetic characteristics depended not on one, but on two and more environmental factors. Apparently similar effects of the factors on the biomass growth and biosynthesis (limiting, inhibition or combined limiting-inhibition) at different values of the kinetic equation constants were studied. Examples of different character of the effects of one or both factors on the growth and biosynthesis are discussed.

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The effect of pH on the culture respiration rate at different concentrations of glucose in the medium was studied. It was found that the hydrogen ions showed their effect irrespective of the subsrate concentration in the medium. In this connection a type of macrokinetic equations of the effect of pH on the growth and antibiotic biosynthesis was chosen.

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A special apparatus with continuous dosing of substrates to flasks was used for experiments on the effect of inorganic phosphorus concentrations on the growth process of Act. aureofaciens and tetracycline biosynthesis. The experimental data showed that the character of the orthophosphorus effect on the mycellium growth and antibiotic biosynthesis was different.

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A low initial rate of the culture growth is an obligatory condition for intensive biosynthesis of tetracycline by Act. aureofaciens in batch fermentations. The mineral phosphorus concentration is a factor limiting the growth rate.

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