Restructuring of the thyroid gland in primary hypothyroidism under the influence of intermittent hypobaric hypoxia.

We studied the effect of intermittent hypobaric hypoxia on morphofunctional characteristics of the thyroid gland during experimental hypothyroidism. Functional activity of the thyroid gland increased in the early period of hypoxia. Morphofunctional parameters reached a constant level with increasing the duration of hypoxia to 7-15 days.

[An experimental model of enteric klebsiellosis].

Acute enteric infection was reproduced in rabbits, used as an experimental model, receiving Aspergillus flavus metabolites with food for 15 days and inoculated rectally with enterotoxigenic strain Klebsiella pneumoniae K24 6723. Pathomorphological study revealed the penetration of Klebsiella into microplicate cells of the intestinal epithelium, the proliferation of bacteria in the lamina propria and in the cupolas of Peyer's patches, as well as in phagolysosomes of leukocytes and macrophages. The lesion of the mucous membrane in both large and small intestine, accompanied by the hyperplasia of lymphoid follicles, was noted.

[Morphological characteristics of the pituitary-gonad system in high altitude hypoxia].

The experiments on male rats showed that their sojourn at high altitude resulted in alterations of functional relationship between the gonadotropic pituitary cells and tests. That was characterized by synthesis inhibition and hormone release by gonadotropocytes. In the testes we found impairments in the barrier function and active substance transport in sustentocytes.

[The structural reorganization of the calcium-regulating glands in body adaptation to high altitude].

The parathyroid cells and thyroid C-cells were studied morphologically, morphometrically and electron microscopically at the altitude of 3200 m. The increase of functional activity of both parathyroid cells and thyroid cells was observed starting from the 7th day of being at the high altitude. This was manifested in the increase of C-cell number, their size and ultrastructurally in the cell organelles hyperplasia and hypertrophy.

[Clinical pathomorphology of the liver and gastric mucosa in peptic ulcer complications].

Tests of the functional state of the liver and indices of the immuno-biological reactivity were studied in 193 patients with complicated forms of the ulcerous disease. The intravital morphological investigation of the liver and gastric mucosa tissues was performed. The correlative relations between the character of changes in the stomach and liver and processes of autoallergy were detected.