Publications by authors named "Taranatee Khan"
Drug resistance remains a significant barrier to effective cancer therapy. Cancer cells evade treatment by reprogramming their metabolism, switching from glycolysis to oxidative phosphorylation (OXPHOS), and relying on alternative carbon sources such as glutamine. These adaptations not only enable tumor survival but also contribute to immune evasion through mechanisms such as reactive oxygen species (ROS) generation and the upregulation of immune checkpoint molecules like PD-L1.
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- Autosomal dominant polycystic kidney disease (ADPKD) leads to kidney damage due to uncontrolled cyst growth and may require a combination of therapies targeting multiple signaling pathways for better treatment outcomes.
- Researchers developed peptide amphiphile micelles containing specific drug combinations (bardoxolone methyl, octreotide, salsalate, pravastatin) to enhance targeted delivery to affected kidney cells.
- Results showed that these RGD micelles significantly improved drug accumulation in the kidneys and increased therapeutic efficacy in ADPKD mouse models compared to free drugs, indicating potential for better treatment strategies.