A Novel Method for Assessing Cerebral Edema, Infarcted Zone and Blood-Brain Barrier Breakdown in a Single Post-stroke Rodent Brain.

Stroke is a major cause of global morbidity and mortality. Middle cerebral artery occlusion (MCAO) has historically been the most common animal model of simulating ischemic stroke. The extent of neurological injury after MCAO is typically measured by cerebral edema, infarct zone, and blood-brain barrier (BBB) permeability.

DIAGNOSTICS AND CORRECTION OF THROMBOHEMORRHAGIC DISORDERS IN PATIENTS WITH GIANT UTERINE MYOMA AT THE PERIOPERATIVE STAGE OF TREATMENT.

The aim of the study was to reduce perioperative blood loss in patients with giant uterine myoma. As a result of studies have provided evidence that the use of anti fibrinolytic therapy as intravenous infusion of tranexamic acid for 30 minutes before the surgery in a dose of 20 mg/kg followed by infusion of 5 mg/kg per hour for the first postoperative day, helped to reduce perioperative blood loss by 29%. Hemoglobin level was higher by 10% (p < 0,05), blood loss was lower by 29% (p < 0,05), the length of stay in hospital was reduced by 24% (p < 0,05) in patients of the second group on the second postoperative day.

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016.

[This corrects the article DOI: 10.1186/s13054-016-1208-6.].

[CHANGES OF THE HEMOSTASIS SYSTEM IN THE INJURED PERSONS IN FRACTURES OF LONG BONES OF THE LOWER EXTREMITIES].

The changes of hemostasis in the injured persons, in the lower extremities long bones fracture were analyzed. Complex dynamic investigation of the hemostasis system was conducted preoperatively in 76 injured persons, in whom long bones of the lower extremities fracture have occurred, and in 31--with injury of meniscus. Instrumental diagnostic method--a low-frequency piezoelectric thromboelastography--was applied for investigation of the blood coagulation system.

[State of the endothelial system in physiological pregnancy and in the event of preeclampsia].

The aim of the study was to examine the state of endothelial system in healthy pregnant women in the third trimester and in pregnant women with severe preeclampsia by determining the number of circulating endothelial cells desquamated at different stages of apoptosis, the method of J. Hladoveka at baseline and after the test with the test stimulus. Data obtained from studies were processed using standard software packages "MedStat" and Microsoft Excel, their analysis.

[The method of integral estimation of a functional status of the hemostatic system].

The instrumental method of the integral assessment of functional state of the hemostasis system using piezoelectric hemoviscosigraphy was elaborated.