Publications by authors named "Tara Vohs"

Article Synopsis
  • Novel near-infrared ratiometric probes were created by combining formyl-functionalized xanthene and methoxybenzene with a xanthene-hemicyanine structure, allowing for precise fluorescence tracking in response to pH changes.
  • The probes demonstrated distinct fluorescence patterns at different pH levels, with specific absorption and emission peaks, indicating their ability to effectively signal pH alterations in various environments.
  • Experimental applications showcased the probes' versatility, including monitoring mitochondrial pH fluctuations and observing cellular responses to conditions like starvation and hypoxia, underlining their potential as tools in cellular research.
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The use of arsenic (As) for various industrial and agricultural applications has led to worldwide environmental contamination. Phytoremediation using hyperaccumulators is a sustainable soil As mitigation strategy. Microbial processes play an important role in the tolerance and uptake of trace elements such as in plants.

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We describe a simple but efficient approach to make fluorescent probes A and B based on rhodol dyes incorporated with salicyaldehyde moiety for monitoring pH changes in mitochondria under oxidative stresses and hypoxia conditions, and for tracking mitophagy processes. Probes A and B possess p values (p ≈ 6.41 and 6.

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Three fluorescent probes , , and that function in the near-infrared wavelengths and utilize pseudo xanthene platforms with an oxygen atom at the 10-position replaced by a [Me-N] group have been created to identify hypoxia via nitroreductase determinations at the 0.04, 0.10, and 0.

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Abnormal levels of glutathione, a cellular antioxidant, can lead to a variety of diseases. We have constructed a near-infrared ratiometric fluorescent probe to detect glutathione concentrations in biological samples. The probe consists of a coumarin donor, which is connected through a disulfide-tethered linker to a rhodamine acceptor.

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Ratiometric near-infrared fluorescent probes ( and ) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0.

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