Streamlining hit discovery and optimization with a yoctoliter scale DNA reactor.

Background: The field of DNA-encoded technology offers a cutting edge approach to creating 10(9) - 10(12)-size small molecule libraries for the rapid identification of drug-like hits. The YoctoReactor(®) (yR) is the newest DNA-encoded technology and features an innovative and fundamentally different design.

Objective: This technology evaluation presents the basic principles of the yR drug discovery technology platform and discusses its potential as an alternative to current hit discovery methods where high quality and selective drug-like hits can be delivered together with instant structure activity relationships (SAR).