Publications by authors named "Tara McCannel"
Article Synopsis
- The study aimed to differentiate iris melanoma from iris nevus by comparing intraocular pressure (IOP) and cup-to-disc ratio (CDR) in affected and unaffected eyes.
- Researchers analyzed data from 39 patients with iris melanoma and 40 with iris nevus, assessing IOP, CDR, and glaucoma diagnoses over nearly 10 years.
- Findings indicated that iris melanoma patients had significantly higher IOP and CDR in the affected eye compared to the unaffected eye, suggesting that IOP and CDR asymmetry could help in diagnosing iris melanoma.
Article Synopsis
- Uveal melanoma (UM) is a rare cancer affecting adults, and there's limited research on its impact on mental health among survivors.* -
- This study investigated how coping strategies and perceptions of illness influence depression levels one year after a UM diagnosis, involving 107 participants.* -
- Results showed that avoidance coping worsened depressive symptoms in those with chronicity perceptions, while approach-oriented coping helped reduce depression for those with similar perceptions, suggesting that both factors play a role in mental health after UM.*
Background/objectives: The purpose of this study is to report cases of choroidal melanoma that developed extrascleral tumour recurrence after treatment with iodine-125 brachytherapy.
Subjects/methods: In this single-institution retrospective observational case series, all instances of biopsy-confirmed orbital melanoma after known intraocular melanoma were reviewed. Tumour characteristics, clinical course, time to recurrence, cytogenetics of initial tumour and recurrence, and presence of intraocular recurrence were documented.
Purpose: To evaluate the mid-term outcomes of pars plana vitrectomy performed for retinal detachment (RD) repair after Boston Type 1 keratoprosthesis (KPro) implantation.
Methods: Retrospective review of medical records of KPro implanted at the Stein Eye Institute presenting with RD and treated by pars plana vitrectomy. Functional success was defined as a postoperative visual acuity maintained within 2 Snellen lines of the corrected distance visual acuity measured before the development of the RD (baseline) and anatomical success as an attached retina after the pars plana vitrectomy.
Objective: Uveal melanoma, a rare eye cancer, presents potential vision loss and life threat. This prospective, longitudinal study interrogated the predictive utility of visual impairment, as moderated by optimism/pessimism, on depressive symptoms in 299 adults undergoing diagnostic evaluation.
Method: Depressive symptoms (Center for Epidemiologic Studies Depression Scale), subjective (Measure of Outcome in Ocular Disease vision subscale) and objective (logarithm of the minimum angle of resolution) visual impairment, and optimism/pessimism (Life Orientation Test-Revised) were assessed before diagnostic evaluation and 1 week, 3 months, and 12 months after diagnosis.
Little is known about contributors to the psychosocial impact of uveal melanoma, a rare cancer. Predictors and outcomes of benefit finding, a potentially favorable outcome, were investigated. Adults (n = 107) completed assessments prior to diagnosis of uveal melanoma and one week, three months and 12 months after diagnosis.
View Article and Find Full Text PDFBackground: Pediatric retinal disorders, although uncommon, can be challenging to assess in the clinic setting and often requires an exam under anesthesia. The purpose of our study was to evaluate the use of ultra-wide field retinal imaging in children without sedation in an outpatient clinic.
Methods: We performed a retrospective case series of patients 18 years or younger who received ultra-wide field imaging over a one year period.
Unlabelled: PRéCIS:: A single-center retrospective review over a 10-year period discovered an 8.6% risk of developing secondary open-angle glaucoma, and a 6.7% risk of neovascular glaucoma after brachytherapy for uveal melanoma.
View Article and Find Full Text PDFPurpose: Metastatic uveal melanoma (UM) has a very poor prognosis and no effective therapy. Despite remarkable advances in treatment of cutaneous melanoma, UM remains recalcitrant to chemotherapy, small-molecule kinase inhibitors, and immune-based therapy.
Methods: We assessed two sets of oxidative phosphorylation (OxPhos) genes within 9858 tumors across 31 cancer types.
Background: The aim of this study was to determine the known radiation exposure, attitudes, and consequent risk modifications among female ocular oncologists in North America who routinely administer radioactive plaque brachytherapy treatment and are members of the International Society of Ocular Oncology.
Methods: Nineteen female ocular oncologists completed an anonymous 17-question radiation exposure survey.
Results: Eleven of the participants chose to routinely wear lead protection during surgery; 8 did not.
Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.
Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg.
Purpose: Episcleral eye plaques provide excellent local control of ocular melanoma, but vision sparing remains a significant problem with 30% or more of patients experiencing significant visual acuity degradation. The use of silicone oil shielding with Iodine-125 plaques has previously been reported to improve critical structure sparing. We hypothesized that the use of Palladium-103 would improve the shielding effectiveness of silicone oil due to the strong energy dependence of the photoelectric effect.
View Article and Find Full Text PDFPurpose: To evaluate visual and surgical outcomes of cataract surgery in eyes with a history of iodine-125 (I) brachytherapy for ocular melanoma.
Setting: Department of Ophthalmology, David Geffen School of Medicine at UCLA and the Stein Eye Institute, Los Angeles, California, USA.
Design: Retrospective case series.
Article Synopsis
- Previous studies indicate that BAP1 levels provide important prognostic information for uveal melanomas, but research on fine needle aspiration biopsies and their correlation with prognosis was lacking.
- An experimental study was conducted with fine needle aspiration biopsies from 113 uveal melanoma patients to assess BAP1 expression alongside chromosome 3 analysis and gene expression profiling.
- The findings show that low BAP1 nuclear expression correlates strongly with monosomy of chromosome 3, suggesting that BAP1 immunocytochemistry could be a valuable prognostic tool for uveal melanoma when sufficient tissue is available.
Importance: Understanding supportive care needs in patients with cancer is important for developing approaches that enhance quality of life and promote satisfaction with care.
Objective: To characterize the nature and frequency of sociodemographic, medical, and psychosocial factors associated with unmet needs in patients with uveal melanoma 1 week and 3 months after diagnosis.
Design, Setting, And Participants: This 3-month, prospective, longitudinal survey study was conducted at a university-based ophthalmology practice from June 1, 2007, to July 1, 2011.
Article Synopsis
- The study aimed to evaluate the agreement between DecisionDx-UM gene expression profiling (GEP) and chromosome 3 analysis using FISH and MLPA in uveal melanoma patients undergoing FNAB during brachytherapy.
- Researchers reviewed data from patients diagnosed with posterior uveal melanoma, identifying two cohorts based on the types of genetic tests performed (FISH for Cohort 1 and MLPA for Cohort 2).
- The findings indicated a discordance rate of 15.9% between GEP and FISH, and 16.3% between GEP and MLPA, highlighting the importance of cautious patient counseling regarding prognosis based on GEP results.
Purpose: Radiation retinopathy remains incompletely characterized and may cause severe vision loss. Ultra-wide-field fluorescein angiography provides a pan-fundus view of vascular alterations caused by radiation treatment and may predict visual and ocular outcomes. We have developed a grading scheme to describe pan-fundus severity and to predict the progression of radiation retinopathy in patients treated for uveal melanoma with iodine-125 brachytherapy.
View Article and Find Full Text PDFAims: The aim of this paper was to compare the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions.
Methods: We analyzed the spectral-domain optical coherence tomography (SD-OCT) features of 9 eyes with optic disc melanocytoma and compared them with those of choroidal melanoma and nevus.
Results And Conclusion: We identified 2 categories of SD-OCT findings in optic disc melanocytoma: (a) type 1, the typical, prominent, hyperpigmented lesion with SD-OCT findings of a hyperreflective, disorganized overlying retina and a posterior hyporeflective shadow, and (b) the less common, atypical, minimally pigmented type 2 lesion overlaid by a relatively well-organized retina that lacks a posterior hyporeflective shadow.
Purpose: To characterize intraoperative findings, surgical approach, and postoperative outcomes in patients undergoing strabismus surgery following plaque brachytherapy for ocular melanoma.
Methods: The records of all patients who underwent plaque brachytherapy for choroidal melanoma between May 2007 and June 2016 were reviewed retrospectively to identify those who subsequently required strabismus surgery.
Results: Of the 461 patients who underwent plaque brachytherapy during the study period, 13 (2.
Juxtapapillary and circumpapillary choroidal melanoma: globe-sparing treatment outcomes with iodine-125 notched plaque brachytherapy.
Graefes Arch Clin Exp Ophthalmol
September 2017
Purpose: Managing juxtapapillary and circumpapillary choroidal melanoma with brachytherapy is challenging because of technical complications with accurate plaque placement and high radiation toxicity given tumor proximity to the optic nerve. We evaluated our center's experience using ultrasound-guided, Iodine (I)-125 notched plaque brachytherapy for treating choroidal melanoma contiguous with (juxtapapillary) and at least partially surrounding the optic disc (circumpapillary).
Methods: All cases of choroidal melanoma treated with I-125 notched plaque brachytherapy at our center from September 2003-December 2013 were retrospectively reviewed.