The role of serum biomarkers in determining systemic inflammation and cardiovascular risk in pseudoexfoliation syndrome.

Purpose: To investigate the role of hematological and atherogenic biomarkers in evaluating systemic inflammation and cardiovascular risk in patients with pseudoexfoliation syndrome.

Methods: This retrospective study included 200 patients, 90 with pseudoexfoliation (PEX) syndrome (Group 1) and 110 healthy controls (Group 2). Twelve-hour fasting blood samples were collected to measure complete blood count, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) (neutrophil x platelet/lymphocyte), systemic inflammatory response index (SIRI) (neutrophil x monocyte/lymphocyte), pan-immune inflammation value (PIV) (neutrophil x platelet x monocyte/lymphocyte), C-reactive protein (CRP), uric acid, glucose, triglycerides (TG), total cholesterol, HDL, LDL, non-HDL, and triglyceride-glucose (TyG) index (Ln (TG [mg/dL] × glucose [mg/dL]/2)).

Bilateral epithelial keratopathy and punctate keratitis due to ribociclib.

Introduction: This report describes a rare occurrence of corneal epithelial keratopathy associated with ribociclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor widely used in breast cancer treatment.

Case Report: An 83-year-old female with a recent breast cancer diagnosis presented with blurred vision during the third cycle of ribociclib treatment. Ocular examination revealed corneal epitheliopathy and fluorescein staining findings.

Feed form and perch design do not interact to production performance, gastrointestinal tract traits, behaviour and welfare of laying hens reared in enriched cages.

1. It was hypothesised that perch material and design may affect utility and maintenance energy demand in laying hens, affecting their feed form preferences and daily feed consumption. Accordingly, perch design and feed form on hen performance, gastrointestinal tract functions and some behavioural and welfare-related traits were studied in laying hens (ATAK-S) reared in enriched colony cages from 24 to 40 weeks of age.

Stenotrophomonas maltophilia endophthalmitis following keratoplasty.

Endophthalmitis is among the most sight-threatening infections in ophthalmology practice. Many microorganisms causing endophthalmitis have been reported. Stenotrophomonas maltophilia is among the rare causes of endophthalmitis and has been reported after cataract surgery, intravitreal injections and ocular trauma.

The effect of Nd:YAG Laser applied in the posterior capsule opacification on retinal and choroidal structures.

Purpose: To assess the effect of neodymium:yttrium-aluminum-garnet (Nd-YAG) laser procedure on the choroid and retina in patients who developed posterior capsular opacification (PCO) after cataract surgery.

Methods: In this study, 32 eyes of 30 patients who underwent Nd:YAG laser treatment for PCO were evaluated. Visual acuity (VA), intraocular pressure (IOP), central macular thickness (CMT) with optical coherence tomography device (OCT), ganglion cell layer (GCL), inner plexiform layer (IPL), retinal nerve fiber layer (RNFL) and subfoveal choroidal thickness (SCT) were measured.

The relation between serum inflammatory marker levels and serous retinal detachment in macular edema secondary to retinal vein occlusion.

Purpose: To assess blood-derived inflammatory markers in macular edema (ME) secondary to retinal vein occlusion (RVO) with and without serous retinal detachment (SRD).

Materials-methods: Treatment-naive patients with ME secondary to RVO were divided into two groups according to the existence of SRD in optical coherence tomography (OCT) images; group 1 consisted of 60 patients with SRD, and group 2 consisted of 60 patients without SRD. Age and gender-matched 60 patients formed group 3 as healthy controls.

Comparison of Pain between First and Second Operated Eyelids after Upper Eyelid Blepharoplasty.

Purpose: To evaluate and compare intraoperative pain during upper eyelid blepharoplasty (UEB) between on first and second operated eyelids.

Methods: In this cross-sectional observational study, the patients were divided into two groups, with group 1 representing 40 patients whose surgery was first started on the right and group 2 representing the other 40 patients who started surgery on the left first. UEB was performed to all patients by the same surgeon under the same and equal amount of local anesthesia.

Ocular side effects of Trametinib and Dabrafenib: a case report.

A 53-year-old man who has stage 4 non-small cell lung carcinoma and treated with Dabrafenib-Trametinib combination chemotherapy; presented with decreased bilateral visual acuity. We checked out slit lamp examination, fundoscopy, optical coherence tomography and fundus fluorescein angiography. In slit lamp biomicroscopy; bilateral posterior synechiae, granulomatous keratic precipitates and + 4 cells in the anterior chamber were detected.

Evaluation of oral health in different types of diabetes mellitus: A cross-sectional retrospective study.

Objective: It was aimed to compare the relationship between oral health and two types of diabetes mellitus (DM) using laboratory findings and oral health parameters.

Material And Method: This retrospective study was conducted between 2021 and 2022. Type-I and Type-II diabetic patients who had laboratory findings and panoramic radiograph taken on the same day was included to the study.

Do Statins Counteract the Effect of Antidiabetic Drugs? Results of the SCEAD Study.

Purpose: Diabetes and dyslipidemia are leading causes of mortality and morbidity. According to international guidelines, statins are the cornerstone of treatment in patients with diabetes and/or dyslipidemia. However, statins and antidiabetic agents have opposite pharmacological effects, because statins, particularly atorvastatin and rosuvastatin, impair glucose homeostasis, increasing the risk of new-onset diabetes, whereas antidiabetic drugs improve glycemic homeostasis.

Pitavastatin: Coronary Atherosclerotic Plaques Changes and Cardiovascular Prevention.

Stains remain the first therapeutic approach in patients with dyslipidemia to control plasma lipids levels and cardiovascular risk. Multiple clinical trials have demonstrated the benefits of statins in reducing major cardiovascular adverse events in primary and secondary prevention. Moreover, in patients with coronary artery disease, statins decrease coronary atherosclerotic plaque volume and composition, inducing atheroma stabilization.

PAIT-Survey Follow-Up: Changes in Albuminuria in Hypertensive Diabetic Patients with Mild-Moderate Chronic Kidney Disease.

Introduction: Albuminuria is an early marker of kidney disease and reduction of albuminuria translates into a decreased occurrence of cardiovascular and renal outcomes.

Aims: To evaluate the changes in the prevalence of albuminuria in diabetic hypertensive patients treated with several combinations of renin-angiotensin aldosterone system with calcium channel blockers.

Methods: We analysed data from 668 unselected patients from the PAIT survey (mean age 60.

The effect of endodontic irrigants on the microtensile bond strength of different dentin adhesives.

Objectives: The aim of this study was to determine the influence of irrigants on bond strength of adhesive systems.

Materials And Methods: Superficial dentin surfaces of 60 extracted molars were divided into 15 groups, according to irrigants and adhesives. In the control groups, surfaces were irrigated with distilled water.

In vitro effect of cavity disinfectants on the bond strength of dentin bonding systems.

Objective: To evaluate the effect of two cavity disinfectants, a 2% chlorhexidine and a 1% benzalkonium chloride solution, on the shear and tensile bond strengths of dentin bonding systems to dentin.

Method And Materials: Superficial dentin was exposed from 84 freshly extracted human third molars. The teeth were randomly assigned to two main groups according to the bonding agent used, either One Step or Optibond Solo.

Technique sensitivity: biological factors contributing to clinical success with various restorative materials.

Since the 1950s, clinicians have relied on various formulations of Ca(OH)2 to stimulate dentin bridge formation. Various studies (Kozlov and Massler, 1966; Massler, 1967; Brännström, 1978; Cox et al., 1987; Snuggs et al.

An in vivo evaluation of hemorrhage control using sodium hypochlorite and direct capping with a one- or two-component adhesive system in exposed nonhuman primate pulps.

Objective: This study evaluated the biologic ability of sodium hypochlorite to control hemorrhage via chemical amputation of the coagulum, to remove dentin chips, to assist healing, and to facilitate formation of a dentinal bridge under two adhesive systems.

Method And Materials: Ninety Class V cavities with mechanical pulpal exposures were placed in the teeth of five adult monkeys and histologically observed. All exposures were prepared with a No.

Response of human pulpal tissue to orthodontic extrusive applications.

The aim of this study was to investigate histologically the human pulp response to orthodontic extrusive force applications. In group 1, 20 teeth were extruded with the use of a fixed sectional orthodontic appliance. In group 2, 20 teeth were extruded by means of 1/4-inch 4.

Human pulp reaction to dentine bonded amalgam restorations: a histologic study.

Objective: The aim of this study was to investigate the human pulp response to Scotchbond Multi Purpose Plus (SMPP) bonding agent in non-exposed Class V cavities.

Methods: SMPP was placed in 24 of 40 cavites according to manufacturer's instructions and the cavities were restored with amalgam. The remaining 16 cavities were capped with a calcium hydroxide formulation (Dycal) sealed with zinc-oxide eugenol, and restored with the amalgam.

A comparative scanning electron microscopic study on the characteristics of demineralized dentin root surface using different tetracycline HCl concentrations and application times.

Background: The use of demineralizing agents has been reported to enhance the degree of connective tissue attachment to denuded roots. Of the agents used, tetracycline HCI has received the most attention.

Methods: The purpose of this study was to evaluate and compare the SEM surface morphology of human root dentin following various concentrations and application times of tetracycline HCl.

Surface finish produced on resin composites by new polishing systems.

Objective: There is a demand for more efficient and finer polishing of resin composite restorations. This study compared the use of some new systems, with new or reduced numbers of abrasive instruments, to polish representative resin composites.

Method And Materials: Super-Snap Rainbow Technique Kit, Sof-Lex Pop-On System, and Enhance Finishing and Polishing System were used to prepare the surfaces of blocks of seven different hybrid or microfilled resin composites.

Pulpal response to a resin-modified glass-ionomer material on nonexposed and exposed monkey pulps.

Objective: This study evaluated the biocompatibility of a resin-modified glass-ionomer material on monkey pulps.

Method And Materials: Standardized Class V cavities were prepared in 112 teeth distributed in six healthy adult monkeys. The resin-modified glass-ionomer cement was placed in 24 nonexposed and 36 exposed pulps according to manufacturer's instructions.

Biocompatibility of primer, adhesive and resin composite systems on non-exposed and exposed pulps of non-human primate teeth.

Purpose: To evaluate the histologic response of 332 non-exposed and 127 exposed monkey pulps applying nine adhesive systems.

Materials And Methods: Class V and Class I cavities were used in non-exposed and exposed monkey pulps at the three ISO usage time intervals.

Results: There were no histologic differences in pulp responses among the nine adhesive systems used in either Class V and/or Class I cavities when compared to pulp responses of Ca(OH)2 controls at the ISO time intervals.

Biocompatibility of Optibond and XR-Bond adhesive systems in nonhuman primate teeth.

This study evaluated the histologic responses of two different adhesive systems on the teeth of seven healthy adult monkeys. Class V cavities in 128 teeth were observed at 7,21 to 27, and 90 to 97 days. Statistical data showed no significant differences in pulp inflammation between the Optibond (Kerr), XR-Bond (Kerr), and IRM (Caulk) groups in pulps at the three time intervals.

Biocompatability of compomer restorative systems on nonexposed dental pulps of primate teeth.

This study evaluated the histologic response of total-etched and nonetched compomer restored cavity preparations. One hundred fifteen class 5 cavity preparations were placed in the teeth of four healthy adult monkeys at 7, 27, and 90 days. A 37% H3PO4 was applied for 10 seconds and rinsed in total-etched preparations.