Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task.

Working memory refers to the temporary retention of a small amount of information used in the execution of a cognitive task. The prefrontal cortex and its connections with thalamic subregions are thought to mediate specific aspects of working memory, including engaging with the hippocampus to mediate memory retrieval. We used an operant delayed-non match to position task, which does not require the hippocampus, to determine roles of the rodent medial prefrontal cortex (mPFC), the nucleus reuniens thalamic region (RE), and their connection.

Transient strain differences in an operant delayed non-match to position task.

Working memory refers to the temporary retention of a small amount of information used in the execution of a cognitive task. Working memory impairments are one of the common hallmarks of many neuropsychiatric and neurological disorders including schizophrenia and Alzheimer's disease. Here, we investigated Fischer 344 and Long-Evans rats for strain and sex differences in working memory using the operant-based DNMTP task.