Cloning and chromosomal localization of the gene coding for human protein kinase CK1.

A cDNA clone coding for human protein kinase CK1 (casein kinase 1) has been isolated and sequenced demonstrating that it corresponds to a homolog of the CK1 alpha form found in bovine brain. The derived amino acid sequence of the human CK1 alpha is identical to the bovine counterpart except that it contains 12 extra amino acids at the carboxyl end. Using this cDNA sequence and PCR amplification, YAC genomic clones that contain this human CK1 alpha sequence have been isolated.

Month at menarche: a re-evaluation of the seasonal hypothesis.

The hypothesis of a dominant or major seasonal factor that produces the winter peak of menarche found in European girls was tested using several Caucasian and Mongolian samples from the northern hemisphere and two Chilean samples. Present results do not support such a hypothesis. The month at menarche of Chilean girls did not show the expected winter peak; February, a winter month in Europe, showed a deep trough in most samples.

Behavioral effects of intracerebral administration of luteinizing hormone releasing hormone (LHRH) in rats.

The effects of LHRH intracerebrally infused on acquisition of conditioned avoidance responses (CARs) and spontaneous motility were studied in adult male rats. The results were the following: 1) LHRH (1 and 2.5 micrograms/rat) administered through a cannula stereotaxically implanted into the lateral ventricle induced an impairment in the acquisition of CARs along with an increase in global motility, rearing, head shaking and grooming behavior; 2) LHRH 1 microgram/rat injected into the hippocampus or nucleus accumbens induced also an impairment in acquisition which is evident 15 min after treatment.

Epidemiologic status of drug abuse in Mexico.

Abuse of alcoholic beverages and tobacco appear to constitute priority public health problems in Mexico, while abuse of other drugs is sufficiently widespread to justify concern. More specifically, a recent national survey (11) found that over 10% of the male subjects 18 to 65 years old met established international criteria for alcohol dependence, while about a quarter of those surveyed were active smokers. A total of 4.

[Epidemiological status of drug abuse in Mexico].

As a country that produces marijuana and opium, and as a route for cocaine traffic to the United States of America, Mexico is experiencing serious social and health problems related to the trafficking, use, and abuse of these drugs and other dependency-producing substances. In 1988 a national survey of addiction was undertaken in which information was collected on the prevalence of the use of alcohol, tobacco, inhalants, marijuana, cocaine, hallucinogens, opium, heroin, narcotic analgesics, sedatives, and tranquilizers. A sample was identified in the population between the ages of 12 and 65 living in urban areas of more than 2,500 inhabitants, which account for approximately 65% of the country's total population.