Publications by authors named "Tapani Koppinen"
Multiple sclerosis (MS) is a progressive autoimmune disease characterized by T-cell mediated demyelination in central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a widely used disease model of MS. Glucocorticoids such as dexamethasone (dex) function as immunosuppressants and are commonly used to treat acute exacerbations of MS.
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- The discovery of meningeal lymphatic vessels (LVs) has sparked interest in their role in brain health, but their growth and upkeep are not well-understood.
- LVs begin to develop after birth, starting near skull openings and spreading along blood vessels and nerves to the surrounding protective layers of the brain and spinal cord.
- Key factors for their development include VEGF-C and VEGFR3, while blocking these pathways can cause regression of these vessels and impair fluid drainage, highlighting their potential for future therapeutic applications.