Publications by authors named "Tapan Sircar"

Background: Patients with breast pain are usually seen in 'one-stop clinic' (OSC) with breast imaging. In the absence of associated red flag features, the incidence of breast cancer is extremely low. With increase in referrals the OSC capacity is over-stretched.

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Background: Negative pressure wound therapy (NPWT) has emerged as an adjunct to reduce wound complication rates in many surgical domains. This study investigated the prophylactic use of PICO NPWT in high-risk patients undergoing oncoplastic and reconstructive breast surgery.

Methods: This was a prospective multicenter national audit.

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Wide local excision is a common procedure in the treatment of breast cancer. Wire-guided localisation (WGL) has been the gold standard for many years; however, several issues have been identified with this technique, and therefore, wire-free techniques have been developed. This scoping review synthesises the available literature comparing wire-guided localisation with the wire-free techniques used in breast-conserving cancer surgery.

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Introduction Skin necrosis is a major concern of morbidity in patients undergoing reconstructive and oncoplastic breast surgery (ROBS) as it may lead to a poor aesthetic outcome, necessitate further surgery, and delay adjuvant chemotherapy and radiotherapy if required postoperatively. Some studies have reported that closed incision negative pressure therapy (ciNPT) immediately after surgery can reduce the incidence of wound complications. Our study aimed to investigate the effect of ciNPT on skin necrosis rate after ROBS.

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Background The rate of upgrading ductal carcinoma in situ (DCIS) to invasive cancer varies widely in the literature with no consensus regarding sentinel lymph node biopsy (SLNB) for DCIS; however, some guidelines do recommend it in the event of a mastectomy. The primary aim of this study was to determine the upgrade rate of DCIS to invasive carcinoma (IC) in patients undergoing mastectomy for DCIS and identify the clinicopathological predicting factors for the upgrade. The secondary aim was to determine the SLNB positivity rate.

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Article Synopsis
  • * Analysis of 93 untreated IBC samples showed that lower-grade tumors had fewer CD4+ cells but more FOXP3+ cells; higher CD20+ cell levels were linked to better chemotherapy responses.
  • * The study found distinct immune cell patterns in various subtypes of IBC, suggesting that understanding these patterns could improve therapies and contribute to developing immunotherapy strategies.
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Carcinomas of primary accessory breast tissue are rare, comprising 0.3-0.6% of all breast cancers and occur most commonly in the axilla.

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Introduction: The National Institute for Clinical Excellence recommends the use of tumour profiling tests to guide adjuvant chemotherapy in breast cancer. The Oncotype DX™ score (Genomic Health) has superseded more traditional tools such as PREDICT in appropriate patients (ER + ve, HER2-ve, lymph node negative and with a Nottingham Prognostic Index [NPI] ≥ 3.4).

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Breast abscess is a common clinical condition mostly caused by However, infections due to mixed organisms are observed in non-lactational women, mostly in smokers. infection causing breast abscess is extremely rare in developed countries. We report a case of subsp (I) serovar Enteritidis breast abscess in a 48-year-old woman, a UK citizen, who had recently travelled abroad.

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Subpectoral breast reconstruction using implants and meshes have been used widely in Europe, the United States and the United Kingdom. Although this technique has several advantages, animation deformity is a well-documented problem. We propose a new grading system to classify breast animation in patients undergoing subpectoral implant based breast reconstruction.

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Article Synopsis
  • MRI is effective in detecting invasive lobular carcinoma (ILC), prompting changes in surgical plans for 26.4% of patients who initially qualified for breast conserving surgery (BCS).
  • Most patients (72 out of 334 MRIs) underwent the imaging shortly after their diagnosis, and initial mastectomy rates were 31.9%, increasing to 36.1% after final assessments.
  • The study found that MRI correlated better with actual cancer sizes in histopathology than mammograms and ultrasounds, resulting in high rates of disease-free survival (95.8%) and overall survival (98.6%) over a median follow-up of 44 months.
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