Hydrogen Evolution of a Unique DNAzyme Composed of Cobalt-Protoporphyrin IX and G-Quadruplex DNA.

Molecular hydrogen (H ) is a clean and renewable fuel that has garnered significant interest in the search for alternatives to fossil fuels. Here, we constructed an artificial DNAzyme composed of cobalt-protoporphyrin IX (CoPP) and G-quadruplex DNA, possessing a unique H O ligand between the CoPP and G-quartet planes. We show for the first time that CoPP-DNAzyme catalyzes photo-induced H production under anaerobic conditions with a turnover number (TON) of 1229 ± 51 over 12 h at pH 6.

Construction of "peptide-hemin/DNA" hybrid-complexes and their peroxidase activities.

-Acetylated microperoxidase-11 and G-quadruplex DNA are shown to form a stable "peptide-hemin/DNA" hybrid-complex, in which the peroxidase activity at the interface between hemin and the G-quartet planes exponentially increases with increasing value.