Publications by authors named "Taowei Wu"
Perineural invasion (PNI) leads to the poor prognosis of head and neck squamous cancer (HNSCC) patients, but the mechanism of PNI remains unclear. Dickkopf-1 (DKK1), a secretory protein in the Wnt signaling pathway, was found indeed upregulated in HNSCC cells and tissues. Higher expression of DKK1 was statistically relevant to T stage, N stage, PNI, and poor prognosis of HNSCC.
View Article and Find Full Text PDF[Tislelizumab monotherapy for the treatment of recurrent/metastatic head and neck squamous cell carcinoma].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
October 2023
Article Synopsis
- This study investigated the safety and effectiveness of tislelizumab, an immunotherapy drug, in patients with recurrent or metastatic head and neck squamous cell carcinoma, analyzing data from six patients treated between 2018 and 2020.
- The results showed that the objective response rate was 50%, with a median progression-free survival of 6.44 months and a median overall survival of 20.07 months, but 66.7% of patients experienced severe side effects.
- The findings indicated a potential link between the drug's effectiveness and immune cell activity, suggesting that immune-related factors play a crucial role in the treatment response to tislelizumab.
Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma.
Otolaryngol Head Neck Surg
September 2023
Objective: Because of the high costs associated with early-stage laryngeal carcinoma diagnosis and prognosis prediction, this study attempts to find valuable targets to establish a novel predictive model by focusing on the aldehyde dehydrogenase 2 (ALDH2) genotype and other peripheral blood markers.
Study Design: Retrospective study.
Setting: Tertiary comprehensive hospital.
Metastasis of head and neck squamous cell carcinoma rarely occurs in hepatic cancer and has a poor prognosis (median survival of 4 months). The efficacy of immunotherapy for these patients remains unknown. Herein, we present a patient with hypopharyngeal carcinoma metastasis to the liver with and mutations together with a combined positive score of 70.
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