Increased corneal sub-basal nerve density in patients with Sjögren syndrome treated with topical cyclosporine A.

Background: To evaluate quantitative and qualitative changes in sub-basal corneal nerves (SBN) via in vivo confocal microscopy in patients with Sjögren syndrome dry eye (SSDE) treated with topical cyclosporine A (CsA).

Design: Prospective, observational, non-randomized study.

Participants: Thirty eyes of 30 patients with SSDE refractory to conventional treatment treated with CsA 0.

Decreased Corneal Sensation and Subbasal Nerve Density, and Thinned Corneal Epithelium as a Result of 360-Degree Laser Retinopexy.

Purpose: To assess the effects of 360-degree laser retinopexy on human corneal subbasal nerve plexus and to investigate correlations among corneal subbasal nerve plexus density, corneal epithelial thickness, and corneal sensitivity.

Design: Prospective, observational, nonrandomized study.

Participants: A total of 15 eyes of 15 patients who underwent pars plana vitrectomy (PPV) with 360-degree laser retinopexy for retinal detachment (RD) and 15 eyes of 15 patients who underwent PPV for macular hole (MH) without laser treatment.

Anatomic Predictive Factors of Acute Corneal Hydrops in Keratoconus: An Optical Coherence Tomography Study.

Purpose: To define the optical coherence tomography (OCT) corneal changes predisposing to acute corneal hydrops among patients with advanced keratoconus.

Design: Retrospective cohort study.

Participants: A total of 191 advanced keratoconic eyes from 191 patients with advanced keratoconus cases were studied.

Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus.

Purpose: To determine whether optical coherence tomography (OCT) epithelial mapping can improve the detection of form fruste keratoconus.

Setting: French National Eye Hospital, Paris 6 Pierre & Marie Curie University, Paris, France.

Design: Retrospective comparative study.

Fourier-domain optical coherence tomography imaging in corneal epithelial basement membrane dystrophy: a structural analysis.

Purpose: To investigate the features of corneal epithelial basement membrane dystrophy using spectral-domain optical coherence tomography (SD OCT) and to examine the reliability of SD OCT in distinguishing epithelial basement membrane dystrophy from the normal cornea.

Design: Diagnostic test study.

Methods: Forty-five individuals with epithelial basement membrane dystrophy and 45 age- and sex-matched controls with normal corneas were examined, and SD OCT scans of their corneas were performed.

Fourier-domain optical coherence tomography imaging in keratoconus: a corneal structural classification.

Objective: To study corneal morphologic changes in a large keratoconic population and to establish a structural optical coherence tomography (OCT) classification.

Design: Cross-sectional, observational study.

Participants: A total of 218 keratoconic eyes from 218 patients and 34 eyes from 34 normal subjects.