Publications by authors named "Taotian Wei"
Although the combination of anti-vascular strategy plus immunotherapy has emerged as the optimal first-line treatment of hepatocellular carcinoma, lack of tumor targeting leads to low antitumor efficacy and serious side effect. Here, we report an ultra-pH-sensitive nanoparticle of gambogenic acid (GNA) encapsulated by poly(ethylene glycol)-poly(2-azepane ethyl methacrylate) (PEG-PAEMA) for tumor-targeting combined therapy of anti-vascular strategy plus immunotherapy. PEG-PAEMA-GNA nanoparticle was quite stable at pH 7.
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- A new cancer treatment using a selective polymer (PEG-PAEMA) has been created that changes activity based on the acidity of the tumor environment, allowing for targeted therapy.
- This polymer can remain inactive at normal pH levels but becomes highly effective against tumors in acidic conditions, showing a significant increase in cancer-killing ability without harming normal cells.
- PEG-PAEMA has proven to be more effective and less toxic than existing treatments in animal models, indicating promising potential for safer, more selective cancer therapy options.