Exploring the complexity of systemic sclerosis etiology by trio whole genome sequencing.

Systemic sclerosis (SSc) is a heterogeneous rare autoimmune fibrosing disorder affecting connective tissue. The etiology of systemic sclerosis is largely unknown and many genes have been suggested as susceptibility loci of modest impact by genome-wide association study (GWAS). Multiple factors can contribute to the pathological process of the disease, which makes it more difficult to identify possible disease-causing genetic alterations.

Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations.

Summary: Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic studies of admixed populations.

Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations.

Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations.

Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology.

Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association studies (GWASs), PRS, hold promise for improving PRS accuracy and generalizability across populations. To establish best practices for leveraging the increasing diversity of genomic studies, we investigated how various factors affect the performance of PRS compared with PRSs constructed from single-ancestry GWASs (PRS). Through extensive simulations and empirical analyses, we showed that PRS overall outperformed PRS in understudied populations, except when the understudied population represented a small proportion of the multi-ancestry GWAS.

Strategies for the Genomic Analysis of Admixed Populations.

Admixed populations constitute a large portion of global human genetic diversity, yet they are often left out of genomics analyses. This exclusion is problematic, as it leads to disparities in the understanding of the genetic structure and history of diverse cohorts and the performance of genomic medicine across populations. Admixed populations have particular statistical challenges, as they inherit genomic segments from multiple source populations-the primary reason they have historically been excluded from genetic studies.

[Effects of soil surface electric field on aggregates breakdown and water erosion in black soil region of Northeast China].

Through quantitatively adjust soil electric field, we investigated the effect of soil electric field on aggregate stability and soil erosion in black soil region of Northeast China with the experiments of wet sieving and rainfall simulation. Results showed that: 1) Soil surface potential absolute value and electric field strength increased with the decreases of electrolyte concentration in bulk solution. Soil electric field strength could reach to 10 V·m.

The mouse curly whiskers () mutations are recessive alleles of hephaestin-like 1 ().

The spontaneous, curly whiskers mutation (abbreviated ) generates kinky, brittle vibrissae in homozygous mice. Although has been mapped to the centromeric end of mouse Chromosome 9, no particular gene has been causally implicated, and this lack of genetic assignment has stymied 's complete molecular and functional analysis. As a foundation for its positional cloning, we have fine-mapped to a small, 0.